用单克隆抗体鉴定产生人α-干扰素的白细胞的表型。
Phenotype of human alpha-interferon producing leucocytes identified by monoclonal antibodies.
作者信息
Abb J, Abb H, Deinhardt F
出版信息
Clin Exp Immunol. 1983 Apr;52(1):179-84.
Abstract
Monoclonal antibodies with specificities for subsets of human leucocytes have been used for the characterization of alpha-interferon (alpha-IFN) producing cells. The production of alpha-IFN was demonstrated to be a function of Ia+ leucocytes. OKT3+ T lymphocytes, BA-1+ B lymphocytes and Leu 7+ natural killer (NK) cells did not contribute to the production of alpha-IFN. OKM1+ monocytes were essential for the production of alpha-IFN in response to bacterial products or leukaemia cells, but were not required for the synthesis of virus- or poly I:C-induced alpha-IFN. The results indicate that alpha-IFN producing cells represent a heterogenous population of cells of the myeloid lineage.
摘要
具有针对人类白细胞亚群特异性的单克隆抗体已被用于鉴定产生α-干扰素（α-IFN）的细胞。已证明α-IFN的产生是Ia⁺白细胞的功能。OKT3⁺T淋巴细胞、BA-1⁺B淋巴细胞和Leu 7⁺自然杀伤（NK）细胞对α-IFN的产生没有贡献。OKM1⁺单核细胞对于响应细菌产物或白血病细胞产生α-IFN至关重要，但对于病毒或聚肌胞苷酸（poly I:C）诱导的α-IFN的合成不是必需的。结果表明，产生α-IFN的细胞代表髓系谱系的异质细胞群体。
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