• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

联合血清CTRP7和CTRP15水平作为胰岛素抵抗和2型糖尿病的新型生物标志物。

Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus.

作者信息

Xue Shiyao, Ling Jiaxiu, Tian Mingyuan, Li Ke, Li Shengbing, Liu Dongfang, Li Ling, Yang Mengliu, Yang Gangyi

机构信息

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, China.

出版信息

Heliyon. 2024 Apr 29;10(9):e30029. doi: 10.1016/j.heliyon.2024.e30029. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e30029
PMID:38726186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11078869/
Abstract

AIMS

This study aimed to examine the alterations in the serum CTRP7 and CTRP15 concentrations in patients newly diagnosed with type 2 diabetes mellitus (T2DM) and to assess the diagnostic potential of the log10 (CTRP7+CTRP15) for insulin resistance (IR) and T2DM.

METHODS

Serum CTRP7, CTRP15, and adiponectin levels were measured using an enzyme-linked immunosorbent assay (ELISA). Bioinformatics analysis was conducted to investigate CTRP7 and CTRP15-related genes and metabolic signaling pathways.

RESULTS

Log10 (CTRP7+CTRP15) levels were notably elevated in the impaired glucose tolerance (IGT) and T2DM cohorts compared with those in the normal control (NGT) cohort. Log10(CTRP7+CTRP15) exhibited positive correlations with HOMA-IR, area under the glucose curve (AUCg), HbA1c%, triglyceride (TG), visceral adiposity index (VAI), body mass index (BMI), and free fatty acid (FFA), levels but negative correlations with adiponectin. Multivariate stepwise regression analysis revealed that HOMA-IR, BMI, HbA1c and FFA levels were independent factors affecting the log10 (CTRP7+CTRP15). Logistic regression analysis revealed that log10 (CTRP7+CTRP15) was independently associated with T2DM and significantly associated with increased risk. Receiver operating characteristic (ROC) curve analysis indicated that the predictive value of log10 (CTRP7+CTRP15) for T2DM and IR was superior to that of CTRP7 or CTRP15 alone. Intervention studies demonstrated that insulin, FFAs and acute exercise contribute to the elevation of serum CTRP7 levels, while hyperglycemia inhibited CTRP7 secretion. Short-term changes in blood glucose, insulin, FFA and acute exercise had minimal effects on serum CTRP15 levels. Bioinformatics analysis revealed that CTRP7 and CTRP15 interact with multiple metabolism-related genes and are enriched in glucose and lipid metabolism-related pathways.

CONCLUSION

Log10 (CTRP7+CTRP15) may serve as a valuable diagnostic marker for the management of metabolic-related diseases, particularly T2DM and IR.

摘要

目的

本研究旨在检测新诊断的2型糖尿病（T2DM）患者血清CTRP7和CTRP15浓度的变化，并评估log10（CTRP7 + CTRP15）对胰岛素抵抗（IR）和T2DM的诊断潜力。

方法

采用酶联免疫吸附测定（ELISA）法检测血清CTRP7、CTRP15和脂联素水平。进行生物信息学分析以研究CTRP7和CTRP15相关基因及代谢信号通路。

结果

与正常对照（NGT）队列相比，糖耐量受损（IGT）和T2DM队列中的log10（CTRP7 + CTRP15）水平显著升高。Log10（CTRP7 + CTRP15）与稳态模型评估胰岛素抵抗（HOMA-IR）、葡萄糖曲线下面积（AUCg）、糖化血红蛋白（HbA1c）％、甘油三酯（TG）、内脏脂肪指数（VAI）、体重指数（BMI）和游离脂肪酸（FFA）水平呈正相关，但与脂联素呈负相关。多因素逐步回归分析显示，HOMA-IR、BMI、HbA1c和FFA水平是影响log10（CTRP7 + CTRP15）的独立因素。逻辑回归分析显示，log10（CTRP7 + CTRP15）与T2DM独立相关且与风险增加显著相关。受试者工作特征（ROC）曲线分析表明，log10（CTRP7 + CTRP15）对T2DM和IR的预测价值优于单独的CTRP7或CTRP15。干预研究表明，胰岛素、FFA和急性运动导致血清CTRP7水平升高,而高血糖抑制CTRP7分泌。血糖、胰岛素、FFA和急性运动的短期变化对血清CTRP15水平影响最小。生物信息学分析显示，CTRP7和CTRP15与多个代谢相关基因相互作用，并富集于葡萄糖和脂质代谢相关途径。

结论

Log10（CTRP7 + CTRP15）可能作为代谢相关疾病，特别是T2DM和IR管理的有价值诊断标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/ab6b57db3ef5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/0c1ef59926aa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/e429afd44997/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/c24d4c8091ce/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/a12474375036/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/ab6b57db3ef5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/0c1ef59926aa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/e429afd44997/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/c24d4c8091ce/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/a12474375036/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffd3/11078869/ab6b57db3ef5/gr5.jpg

相似文献

1
Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus.联合血清CTRP7和CTRP15水平作为胰岛素抵抗和2型糖尿病的新型生物标志物。
Heliyon. 2024 Apr 29;10(9):e30029. doi: 10.1016/j.heliyon.2024.e30029. eCollection 2024 May 15.
2
Increased circulating level of CTRP15 in patients with type 2 diabetes mellitus and its relation with inflammation and insulin resistance.2型糖尿病患者循环中CTRP15水平升高及其与炎症和胰岛素抵抗的关系。
J Diabetes Metab Disord. 2021 Sep 4;20(2):1499-1504. doi: 10.1007/s40200-021-00892-2. eCollection 2021 Dec.
3
CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross-Sectional and Intervention Studies In and In .CTRP7 是与胰岛素抵抗和氧化应激相关的生物标志物：横断面和干预研究在 和 中。
Oxid Med Cell Longev. 2022 Mar 23;2022:6877609. doi: 10.1155/2022/6877609. eCollection 2022.
4
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome.循环 CTRP7 是代谢综合征的潜在预测因子。
Front Endocrinol (Lausanne). 2021 Nov 11;12:774309. doi: 10.3389/fendo.2021.774309. eCollection 2021.
5
Circulating C1q/TNF-related protein isoform 15 is a marker for the presence of metabolic syndrome.循环 C1q/TNF 相关蛋白异构体 15 是代谢综合征存在的标志物。
Diabetes Metab Res Rev. 2019 Jan;35(1):e3085. doi: 10.1002/dmrr.3085. Epub 2018 Nov 8.
6
Higher serum level of CTRP15 in patients with coronary artery disease is associated with disease severity, body mass index and insulin resistance.冠心病患者血清 CTRP15 水平升高与疾病严重程度、体重指数和胰岛素抵抗有关。
Arch Physiol Biochem. 2022 Feb;128(1):276-280. doi: 10.1080/13813455.2019.1675713. Epub 2019 Oct 12.
7
Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance.血清中 Meteorin 样蛋白（Metrnl）水平在新诊断的 2 型糖尿病患者中升高，并与胰岛素抵抗相关。
Med Sci Monit. 2019 Mar 31;25:2337-2343. doi: 10.12659/MSM.915331.
8
Value of simple clinical parameters to predict insulin resistance among newly diagnosed patients with type 2 diabetes in limited resource settings.在资源有限的环境下，用于预测新诊断 2 型糖尿病患者胰岛素抵抗的简单临床参数的价值。
PLoS One. 2021 Mar 31;16(3):e0248469. doi: 10.1371/journal.pone.0248469. eCollection 2021.
9
Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associated with polycystic ovary syndrome.血浆补体 C1q/肿瘤坏死因子相关蛋白 15 浓度与多囊卵巢综合征有关。
PLoS One. 2022 Jun 14;17(6):e0263658. doi: 10.1371/journal.pone.0263658. eCollection 2022.
10
Relationship between serum betatrophin levels and the first-phase of glucose-stimulated insulin secretion.血清 betatrophin 水平与葡萄糖刺激的胰岛素分泌第一时相之间的关系。
Obes Res Clin Pract. 2018 Jan-Feb;12(Suppl 2):9-15. doi: 10.1016/j.orcp.2016.08.004. Epub 2016 Aug 21.

引用本文的文献

1
Myonectin and metabolic health: a systematic review.肌连接蛋白与代谢健康：一项系统综述
Front Endocrinol (Lausanne). 2025 Jul 16;16:1557142. doi: 10.3389/fendo.2025.1557142. eCollection 2025.
2
Identification of 10 differentially expressed genes involved in the tumorigenesis of cervical cancer next-generation sequencing.基于下一代测序的宫颈癌发生中 10 个差异表达基因的鉴定。
PeerJ. 2024 Oct 2;12:e18157. doi: 10.7717/peerj.18157. eCollection 2024.

本文引用的文献

1
CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross-Sectional and Intervention Studies In and In .CTRP7 是与胰岛素抵抗和氧化应激相关的生物标志物：横断面和干预研究在 和 中。
Oxid Med Cell Longev. 2022 Mar 23;2022:6877609. doi: 10.1155/2022/6877609. eCollection 2022.
2
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1.CTRP15 通过增加 ABCA1 的表达促进巨噬细胞胆固醇外流并减轻动脉粥样硬化。
J Physiol Biochem. 2022 Aug;78(3):653-666. doi: 10.1007/s13105-022-00885-6. Epub 2022 Mar 14.
3
Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome.
循环 CTRP7 是代谢综合征的潜在预测因子。
Front Endocrinol (Lausanne). 2021 Nov 11;12:774309. doi: 10.3389/fendo.2021.774309. eCollection 2021.
4
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review.运动在肌肉因子、肝因子、骨因子、脂肪因子之间的相互作用以及炎症调节中的作用，以实现能量底物再分布和脂肪质量损失：综述。
Nutrients. 2020 Jun 26;12(6):1899. doi: 10.3390/nu12061899.
5
The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: Focus on type 2 diabetes and cardiovascular diseases.C1q/TNF 相关蛋白（CTRPs）在肥胖相关代谢紊乱发病机制中的作用：聚焦 2 型糖尿病和心血管疾病。
Life Sci. 2020 Sep 1;256:117913. doi: 10.1016/j.lfs.2020.117913. Epub 2020 Jun 8.
6
Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome.多囊卵巢综合征患者血清肌联蛋白水平降低与代谢及激素紊乱的相关性研究。
Gynecol Endocrinol. 2020 Nov;36(11):947-950. doi: 10.1080/09513590.2020.1751109. Epub 2020 Apr 21.
7
Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion.中心 Sfrp5 调节肝葡萄糖通量和 VLDL-甘油三酯分泌。
Metabolism. 2020 Feb;103:154029. doi: 10.1016/j.metabol.2019.154029. Epub 2019 Nov 23.
8
The reactome pathway knowledgebase.Reactome 通路知识库。
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503. doi: 10.1093/nar/gkz1031.
9
Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus.肥胖症和2型糖尿病患者的循环血清肌连接蛋白水平
Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):528-534. doi: 10.1055/a-0896-8548. Epub 2019 Jul 24.
10
The potential of adipokines as biomarkers and therapeutic agents for vascular complications in type 2 diabetes mellitus.脂肪细胞因子作为 2 型糖尿病血管并发症的生物标志物和治疗药物的潜力。
Cytokine Growth Factor Rev. 2019 Aug;48:32-39. doi: 10.1016/j.cytogfr.2019.06.002. Epub 2019 Jun 15.