Shakeel Varda, Hussain Gul Iftikhar, John Peter, Bhatti Attya
Thermal Transport Laboratory, School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad, Pakistan.
Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Saudi Pharm J. 2024 Jun;32(6):102066. doi: 10.1016/j.jsps.2024.102066. Epub 2024 Apr 9.
Nanotechnology has transformed drug delivery, offering opportunities to enhance treatment outcomes while minimizing adverse effects. This study focuses on gelatin-coated cobalt and manganese ferrite nanoparticles for potential drug delivery applications. The synthesis involved a co-precipitation method, and the nanoparticles were characterized using various techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, and vibrating sample magnetometer (VSM). Results revealed stable structures, distinct chemical features introduced by gelatin coating, and unique magnetic properties. The hemolysis assay demonstrated reduced hemolytic activity with gelatin coating, enhancing biocompatibility. Drug release studies indicated differential release profiles, with gelatin-coated cobalt ferrite exhibiting higher drug release compared to gelatin-coated manganese ferrite. The Higuchi model supported diffusion-controlled drug release for gelatin-coated cobalt ferrite. These findings suggest the potential of gelatin-coated ferrite nanoparticles for controlled and targeted drug delivery, highlighting their significance in advancing nanomedicine.
纳米技术已经改变了药物递送方式，为提高治疗效果同时将副作用降至最低提供了机会。本研究聚焦于用于潜在药物递送应用的明胶包覆的钴铁氧体和锰铁氧体纳米颗粒。合成过程采用共沉淀法，并用多种技术对纳米颗粒进行了表征，包括X射线衍射（XRD）、扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）、拉曼光谱和振动样品磁强计（VSM）。结果显示出稳定的结构、明胶包覆引入的独特化学特征以及独特的磁性。溶血试验表明明胶包覆降低了溶血活性，增强了生物相容性。药物释放研究表明了不同的释放曲线，明胶包覆的钴铁氧体比明胶包覆的锰铁氧体表现出更高的药物释放率。Higuchi模型支持明胶包覆的钴铁氧体的扩散控制药物释放。这些发现表明明胶包覆的铁氧体纳米颗粒在可控和靶向药物递送方面的潜力，凸显了它们在推进纳米医学方面的重要性。
