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使用CuBr催化剂由吡啶、苯乙酮和缺电子烯烃高效无溶剂合成中氮茚。

Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes.

作者信息

Zhang Xueguo, Zhang Jianpeng, Liu Zhengyi, Bi Wenxuan, Shen Jian, Li Guang

机构信息

Department of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China.

出版信息

Molecules. 2024 Apr 29;29(9):2061. doi: 10.3390/molecules29092061.

DOI:10.3390/molecules29092061
PMID:38731552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085153/
Abstract

Herein, we have developed a new approach for the synthesis of indolizine via Cu-catalyzed reaction of pyridine, acetophenone, and nitroolefin under mild conditions in high yields. This reaction involved the formation of C-N and C-C bonds and new indolizine compounds with high stereoselectivity and excellent functional group tolerance.

摘要

在此，我们开发了一种通过铜催化吡啶、苯乙酮和硝基烯烃在温和条件下高产率反应来合成中氮茚的新方法。该反应涉及碳氮键和碳碳键的形成以及具有高立体选择性和出色官能团耐受性的新型中氮茚化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/761b2f642852/molecules-29-02061-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/3e194a7e59aa/molecules-29-02061-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/3263204f6a7c/molecules-29-02061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/aa2b9c8077ca/molecules-29-02061-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/761b2f642852/molecules-29-02061-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/3e194a7e59aa/molecules-29-02061-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/3263204f6a7c/molecules-29-02061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/aa2b9c8077ca/molecules-29-02061-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db3d/11085153/761b2f642852/molecules-29-02061-sch003.jpg

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