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用于药物递送系统的有机硫基聚合物的进展

Advances in Organosulfur-Based Polymers for Drug Delivery Systems.

作者信息

Islam Fawad, Zeng Qingle

机构信息

College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China.

出版信息

Polymers (Basel). 2024 Apr 25;16(9):1207. doi: 10.3390/polym16091207.

DOI:10.3390/polym16091207
PMID:38732676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085353/
Abstract

Organosulfur-based polymers have unique properties that make them useful for targeted and managed drug delivery, which can improve therapy while reducing side effects. This work aims to provide a brief review of the synthesis strategies, characterization techniques, and packages of organosulfur-based polymers in drug delivery. More importantly, this work discusses the characterization, biocompatibility, controlled release, nanotechnology, and targeted therapeutic aspects of these important structural units. This review provides not only a good comprehension of organosulfur-based polymers but also an insightful discussion of potential future prospectives in research. The discovery of novel organosulfur polymers and innovations is highly expected to be stimulated in order to synthesize polymer prototypes with increased functional accuracy, efficiency, and low cost for many industrial applications.

摘要

基于有机硫的聚合物具有独特的性能,使其可用于靶向和可控药物递送,这既能改善治疗效果,又能减少副作用。本文旨在简要综述基于有机硫的聚合物在药物递送中的合成策略、表征技术和包装形式。更重要的是,本文讨论了这些重要结构单元的表征、生物相容性、控释、纳米技术和靶向治疗方面。本综述不仅能让人很好地理解基于有机硫的聚合物,还能对未来研究的潜在前景进行有见地的讨论。人们高度期望能激发新型有机硫聚合物的发现和创新,以便合成功能准确性、效率更高且成本更低的聚合物原型,用于许多工业应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/5717055dbe08/polymers-16-01207-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/10907c3e7d9f/polymers-16-01207-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/d67cc875f7f2/polymers-16-01207-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/582bdb51e00e/polymers-16-01207-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/bebbae586638/polymers-16-01207-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/28eacd147eae/polymers-16-01207-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/a12729241b56/polymers-16-01207-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/a9a7bfa854c7/polymers-16-01207-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/454df8bb955a/polymers-16-01207-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/8b38c3376cda/polymers-16-01207-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/5717055dbe08/polymers-16-01207-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/10907c3e7d9f/polymers-16-01207-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/d67cc875f7f2/polymers-16-01207-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/582bdb51e00e/polymers-16-01207-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/bebbae586638/polymers-16-01207-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/28eacd147eae/polymers-16-01207-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/a12729241b56/polymers-16-01207-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/a9a7bfa854c7/polymers-16-01207-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/454df8bb955a/polymers-16-01207-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/8b38c3376cda/polymers-16-01207-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb22/11085353/5717055dbe08/polymers-16-01207-sch010.jpg

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Phytother Res. 2024 Jan;38(1):331-348. doi: 10.1002/ptr.8042. Epub 2023 Oct 26.
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Zwitterionic Polymeric Sulfur Ylides with Minimal Charge Separation Open a New Generation of Antifouling and Bactericidal Materials.两性离子型聚硫叶立德电荷分离最小化:新一代抗菌防污材料问世。
Angew Chem Int Ed Engl. 2023 Oct 9;62(41):e202308971. doi: 10.1002/anie.202308971. Epub 2023 Sep 1.
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