Bhatt Pankaj, Kumar Vipin, Subramaniyan Vetriselvan, Nagarajan Kandasamy, Sekar Mahendran, Chinni Suresh V, Ramachawolran Gobinath
KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad 201206, Uttar Pradesh, India.
Department of Pharmaceutical Sciences, Gurukul Kangri (Deemed to Be University), Haridwar 249404, Uttarakhand, India.
Pharmaceutics. 2023 Aug 1;15(8):2066. doi: 10.3390/pharmaceutics15082066.
Natural polymers have attracted significant attention in drug delivery applications due to their biocompatibility, biodegradability, and versatility. However, their surface properties often limit their use as drug delivery vehicles, as they may exhibit poor wettability, weak adhesion, and inadequate drug loading and release. Plasma treatment is a promising surface modification technique that can overcome these limitations by introducing various functional groups onto the natural polymer surface, thus enhancing its physicochemical and biological properties. This review provides a critical overview of recent advances in the plasma modification of natural polymer-based drug delivery systems, with a focus on controllable plasma treatment techniques. The review covers the fundamental principles of plasma generation, process control, and characterization of plasma-treated natural polymer surfaces. It discusses the various applications of plasma-modified natural polymer-based drug delivery systems, including improved biocompatibility, controlled drug release, and targeted drug delivery. The challenges and emerging trends in the field of plasma modification of natural polymer-based drug delivery systems are also highlighted. The review concludes with a discussion of the potential of controllable plasma treatment as a versatile and effective tool for the surface functionalization of natural polymer-based drug delivery systems.
天然聚合物因其生物相容性、生物可降解性和多功能性，在药物递送应用中受到了广泛关注。然而，它们的表面性质常常限制了其作为药物递送载体的应用，因为它们可能表现出润湿性差、粘附力弱以及药物负载和释放不足等问题。等离子体处理是一种很有前景的表面改性技术，它可以通过在天然聚合物表面引入各种官能团来克服这些限制，从而增强其物理化学和生物学性质。本文综述了基于天然聚合物的药物递送系统等离子体改性的最新进展，重点介绍了可控等离子体处理技术。综述涵盖了等离子体产生的基本原理、过程控制以及经等离子体处理的天然聚合物表面的表征。讨论了基于等离子体改性的天然聚合物的药物递送系统的各种应用，包括改善生物相容性、控制药物释放和靶向药物递送。还强调了基于天然聚合物的药物递送系统等离子体改性领域的挑战和新趋势。综述最后讨论了可控等离子体处理作为一种通用且有效的工具用于基于天然聚合物的药物递送系统表面功能化的潜力。
