Gurian L E, Rogoff T M, Ware A J, Jordan R E, Combes B, Gilliam J N
Hepatology. 1985 May-Jun;5(3):397-402. doi: 10.1002/hep.1840050309.
We have evaluated the immunologic characteristics often associated with systemic lupus erythematosus in a series of patients with a variety of different liver diseases. Antibody to double-stranded DNA as measured by the Farr assay was detected frequently in patients with various forms of liver disease. No patient with liver disease, including those with a presumed immunologic etiology, was found to have antibody to double-stranded DNA using more specific assays. Other immunologic phenomena such as the presence of immunofluorescent staining at the dermal-epidermal junction in the lupus band test, circulating immune complexes and the presence of antinuclear antibody were present in a number of patients with different forms of liver disease. The absence of antibody to double-stranded DNA in patients with liver disease suggests that there may be a true immunologic distinction between systemic lupus erythematosus and chronic active ("lupoid") hepatitis.
我们评估了一系列患有各种不同肝脏疾病的患者中常与系统性红斑狼疮相关的免疫学特征。通过Farr试验检测的双链DNA抗体在各种形式的肝病患者中经常被检测到。使用更特异的检测方法，未发现包括那些假定有免疫病因的肝病患者有双链DNA抗体。其他免疫现象，如狼疮带试验中真皮-表皮交界处的免疫荧光染色、循环免疫复合物以及抗核抗体的存在，在许多不同形式的肝病患者中也有出现。肝病患者中缺乏双链DNA抗体表明系统性红斑狼疮与慢性活动性（“狼疮样”）肝炎之间可能存在真正的免疫学差异。
