UNIR Health Sciences School and Medical Center, Madrid, Spain.
UNIR Health Sciences School and Medical Center, Madrid, Spain; Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Int J Infect Dis. 2024 Aug;145:107089. doi: 10.1016/j.ijid.2024.107089. Epub 2024 May 9.
Listeria monocytogenes (LM) is a health threat worldwide given its high mortality and the growing of high-risk susceptible populations.
All hospitalizations with a diagnosis of LM in the National Registry of Hospital Discharges were examined in Spain from 2000 to 2021.
A total of 8152 hospital admissions with LM were identified. The mean age was 59.5 years and 48% were immunosuppressed (IS). The rate of LM hospitalizations increased from 5 per 1 million population in 2000 to 8.9 in 2021 (p < 0.001). A foodborne outbreak in Andalusia determined a sharp increase in admissions with LM during 2019. The COVID-19 pandemic and lockdowns were associated with a decrease in LM admissions. The overall in-hospital mortality was 16.7%. The number of deaths in patients hospitalized with LM rose from 7.8 per 100,000 deceased in 2000 to 18 in 2021 (p < 0.001). After adjustment, age >65 years (odds ratio [OR] = 2.16), sepsis (OR = 2.60), meningoencephalitis (OR = 1.72), endocarditis (OR = 2.0), neonatal listeriosis (OR = 2.10) and IS (OR = 2.09) were associated with mortality.
The number of patients hospitalized with LM in Spain has increased significantly from 2000 to 2021. The increase in the rate of admissions and deaths was largely driven by the growing proportion of elderly and IS patients.
李斯特菌（LM）是一种对全球健康构成威胁的病原体，其死亡率高，且高危易感人群不断增加。
本研究在西班牙对 2000 年至 2021 年国家住院患者登记系统中所有因 LM 住院的病例进行了分析。
共确定了 8152 例 LM 住院患者。患者平均年龄为 59.5 岁，48%为免疫抑制患者（IS）。LM 住院率从 2000 年的每百万人 5 例增加到 2021 年的 8.9 例（p < 0.001）。安达卢西亚地区的一次食源性暴发导致 2019 年 LM 住院人数急剧增加。COVID-19 大流行和封锁措施与 LM 住院人数减少相关。总体院内死亡率为 16.7%。2000 年每 10 万名死亡患者中因 LM 死亡的人数为 7.8 例，2021 年增加到 18 例（p < 0.001）。校正年龄>65 岁（比值比 [OR] = 2.16）、败血症（OR = 2.60）、脑膜脑炎（OR = 1.72）、心内膜炎（OR = 2.0）、新生儿李斯特菌病（OR = 2.10）和 IS（OR = 2.09）与死亡率相关。
西班牙因 LM 住院的患者人数从 2000 年到 2021 年显著增加。入院率和死亡率的增加在很大程度上是由于老年和 IS 患者比例的增加。
