Wu Jiang-Hong, Bao Quan-Wei, Wang Shao-Kang, Zhou Pan-Yu, Xu Shuo-Gui
Department of Emergency, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Trauma Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Chin J Traumatol. 2025 May;28(3):157-163. doi: 10.1016/j.cjtee.2024.04.003. Epub 2024 Apr 25.
The Masquelet technique, also known as the induced membrane technique, is a surgical technique for repairing large bone defects based on the use of a membrane generated by a foreign body reaction for bone grafting. This technique is not only simple to perform, with few complications and quick recovery, but also has excellent clinical results. To better understand the mechanisms by which this technique promotes bone defect repair and the factors that require special attention in practice, we examined and summarized the relevant research advances in this technique by searching, reading, and analysing the literature. Literature show that the Masquelet technique may promote the repair of bone defects through the physical septum and molecular barrier, vascular network, enrichment of mesenchymal stem cells, and high expression of bone-related growth factors, and the repair process is affected by the properties of spacers, the timing of bone graft, mechanical environment, intramembrane filling materials, artificial membrane, and pharmaceutical/biological agents/physical stimulation.
Masquelet技术，也称为诱导膜技术，是一种基于利用异物反应产生的膜进行骨移植来修复大的骨缺损的外科技术。该技术不仅操作简单，并发症少且恢复快，而且临床效果极佳。为了更好地理解该技术促进骨缺损修复的机制以及在实践中需要特别关注的因素，我们通过检索、阅读和分析文献，对该技术的相关研究进展进行了考察和总结。文献表明，Masquelet技术可能通过物理隔膜和分子屏障、血管网络、间充质干细胞富集以及骨相关生长因子的高表达来促进骨缺损的修复，并且修复过程受间隔物的性质、骨移植的时机、力学环境、膜内填充材料、人工膜以及药物/生物制剂/物理刺激的影响。
