Jamalipour Soufi Ghazaleh, Hekmatnia Ali, Hekmatnia Farzaneh, Zarei Andrew Parviz, Shafieyoon Shamim, Azizollahi Sara, Ghazanfari Hashemi Mohamad, Riahi Farshad
Department of Radiology, Isfahan University of Medical Sciences Isfahan, Iran.
Department of Radiology, St George's Hospital London, UK.
Am J Nucl Med Mol Imaging. 2024 Apr 25;14(2):97-109. doi: 10.62347/QPAS5990. eCollection 2024.
Infection with the Human Immunodeficiency Virus (HIV) is one of the most pressing issues facing public health on a worldwide scale. Currently, HIV-related lymphoma is the most common cause of death among people living with HIV, and warrants more attention. The unique challenges associated with HIV-related lymphoma management derive from the underlying HIV infection and its immunosuppressive effects. F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) has gained significant prominence in the past few years as a valuable diagnostic and therapeutic instrument for the treatment of HIV-related lymphoma. This review will start with an overview of the subtypes, risk factors, and therapeutic choices for individuals with HIV-related lymphoma. We will then briefly discuss the current application of F-FDG PET/CT in the medical management of HIV-related lymphoma patients, followed by the initial staging of the disease, the evaluation of therapeutic response, the prediction of prognostic outcomes, the decision-making process for radiotherapy guided by PET findings, and the distinguishing of various diagnoses.
感染人类免疫缺陷病毒（HIV）是全球公共卫生面临的最紧迫问题之一。目前，与HIV相关的淋巴瘤是HIV感染者中最常见的死亡原因，值得更多关注。与HIV相关淋巴瘤管理相关的独特挑战源于潜在的HIV感染及其免疫抑制作用。在过去几年中，氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）作为治疗HIV相关淋巴瘤的一种有价值的诊断和治疗手段已变得非常突出。本综述将首先概述HIV相关淋巴瘤患者的亚型、危险因素和治疗选择。然后，我们将简要讨论F-FDG PET/CT在HIV相关淋巴瘤患者医疗管理中的当前应用，接着是疾病的初始分期、治疗反应评估、预后结果预测、PET检查结果指导下的放射治疗决策过程以及各种诊断的鉴别。
