Janssen Silvie H M, Vlooswijk Carla, Bijlsma Rhodé M, Kaal Suzanne E J, Kerst Jan Martijn, Tromp Jacqueline M, Bos Monique E M M, van der Hulle Tom, Lalisang Roy I, Nuver Janine, Kouwenhoven Mathilde C M, van der Graaf Winette T A, Husson Olga
Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.
Department of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX, Amsterdam, the Netherlands.
J Cancer Surviv. 2024 May 13. doi: 10.1007/s11764-024-01597-0.
With 5-year survival rates > 85%, gaining insight into the long-term and late health-related conditions of cancer survivors diagnosed in adolescence and young adulthood is of utmost importance to improve their quantity and quality of survival. This study examined the prevalence of and factors associated with, patient-reported health-related conditions and their latency times among long-term adolescent and young adult (AYA) cancer survivors.
AYA cancer survivors (5-20 years after diagnosis) were identified by the population-based Netherlands Cancer Registry (NCR), and invited to participate in the SURVAYA questionnaire study. Participants reported the prevalence and date of diagnosis of health-related conditions. Clinical data were retrieved from the NCR.
Three thousand seven hundred seventy-six AYA cancer survivors (response rate 33.4%) were included for analyses. More than half of the AYAs (58.5%) experienced health-related conditions after their cancer diagnosis, of whom 51.4% were diagnosed with two or more conditions. Participants reported conditions related to vision (15.0%), digestive system (15.0%), endocrine system (14.1%), cardiovascular system (11.7%), respiratory system (11.3%), urinary tract system (10.9%), depression (8.6%), hearing (7.4%), arthrosis (6.9%), secondary malignancy (6.4%), speech-, taste and smell (4.5%), and rheumatoid arthritis (2.1%). Time since diagnosis, tumor type, age at diagnosis, and educational level were most frequently associated with a health-related condition.
A significant proportion of long-term AYA cancer survivors report having one or more health-related conditions.
Future research should focus on better understanding the underlying mechanisms of, and risk factors for, these health-related conditions to support the development and implementation of risk-stratified survivorship care for AYA cancer survivors to further improve their outcomes.
NCT05379387.
鉴于5年生存率超过85%，深入了解青少年和青年期确诊的癌症幸存者的长期和晚期健康相关状况对于提高他们的生存数量和质量至关重要。本研究调查了长期青少年和青年期（AYA）癌症幸存者中患者报告的健康相关状况的患病率、相关因素及其潜伏时间。
通过基于人群的荷兰癌症登记处（NCR）识别AYA癌症幸存者（诊断后5 - 20年），并邀请他们参与SURVAYA问卷调查研究。参与者报告健康相关状况的患病率和诊断日期。临床数据从NCR中检索。
纳入3776名AYA癌症幸存者（回复率33.4%）进行分析。超过一半的AYA（58.5%）在癌症诊断后经历了健康相关状况，其中51.4%被诊断出患有两种或更多种状况。参与者报告的状况涉及视力（15.0%）、消化系统（15.0%）、内分泌系统（14.1%）、心血管系统（11.7%）、呼吸系统（11.3%）、泌尿系统（10.9%）、抑郁症（8.6%）、听力（7.4%）、关节病（6.9%）、继发性恶性肿瘤（6.4%）、言语、味觉和嗅觉（4.5%）以及类风湿性关节炎（2.1%）。自诊断以来的时间、肿瘤类型、诊断时年龄和教育水平与健康相关状况最常相关。
相当一部分长期AYA癌症幸存者报告患有一种或多种健康相关状况。
未来的研究应专注于更好地理解这些健康相关状况的潜在机制和危险因素，以支持为AYA癌症幸存者制定和实施风险分层的生存护理，从而进一步改善他们的预后。
NCT05379387
