Li Wengao, Xu Yining, Luo Xian, Wen Youlu, Ding Kairong, Xu Wenjing, Garg Samradhvi, Yang Yuan, Sun Hengwen
Department of Psychiatry, Guangdong 999 Brain Hospital, Guangzhou, Guangdong, 510515, People's Republic of China.
Department of Nursing, Guangzhou First People's Hospital, the Second Affiliated Hospital, South China University of Technology, Guangzhou, Guangdong, 510000, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Aug 25;18:1843-1854. doi: 10.2147/NDT.S376408. eCollection 2022.
Anxiety, depression, and pain are highly interactive with each other in adolescent and young adult (AYA) cancer patients. This study aims to map out the connectivity between anxiety, depression and pain symptoms amongst Chinese AYA cancer patients from the perspective of a network model.
Two hundred and eighteen AYA patients, aged between 15 and 39 years at diagnosis; completed the Patient Health Questionnaire (PHQ), Generalized Anxiety Disorder (GAD), and McGill Pain Questionnaire-Visual Analogue Scale (MPQ-VAS). Network analyses were performed.
In all, 38.07% (95% CI = 31.58-44.57%) of the participants reported depression, 30.73% (95% CI = 24.56-36.91%) reported anxiety, and 14.22% (95% CI = 9.55-18.89%) reported current pain. The generated network illustrated that anxiety, depression and pain community were well connected. In the network, "having trouble relaxing" (GAD4, node strength = 1.182), "uncontrollable worry" (GAD2, node strength = 1.165), and "sad mood" (PHQ2, node strength = 1.144) were identified as the most central symptoms, while "uncontrollable worry" (GAD2, bridge strength = 0.645), "guilty" (PHQ6, bridge strength = 0.545), and "restlessness" (GAD5, bridge strength = 0.414) were the key bridging symptoms that connected different communities.
Anxiety, depression and pain symptoms are highly interactive with each other. Alleviating AYA cancer patient's excessive worries might be helpful in improving the patient's co-occurring anxiety, depression and pain symptoms.
焦虑、抑郁和疼痛在青少年及青年（AYA）癌症患者中相互作用极强。本研究旨在从网络模型的角度描绘中国AYA癌症患者焦虑、抑郁和疼痛症状之间的关联性。
218例确诊时年龄在15至39岁之间的AYA患者完成了患者健康问卷（PHQ）、广泛性焦虑障碍问卷（GAD）和麦吉尔疼痛问卷视觉模拟量表（MPQ-VAS）。进行了网络分析。
总体而言，38.07%（95%置信区间=31.58-44.57%）的参与者报告有抑郁，30.73%（95%置信区间=24.56-36.91%）报告有焦虑，14.22%（95%置信区间=9.55-18.89%）报告有当前疼痛。生成的网络表明焦虑、抑郁和疼痛群落联系紧密。在该网络中，“难以放松”（GAD4，节点强度=1.182）、“无法控制的担忧”（GAD2，节点强度=1.165）和“悲伤情绪”（PHQ2，节点强度=1.144）被确定为最核心的症状，而“无法控制的担忧”（GAD2，桥接强度=0.645）、“内疚”（PHQ6，桥接强度=0.545）和“坐立不安”（GAD5，桥接强度=0.414）是连接不同群落的关键桥接症状。
焦虑、抑郁和疼痛症状相互作用极强。减轻AYA癌症患者的过度担忧可能有助于改善患者同时出现的焦虑、抑郁和疼痛症状。
