Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany.
Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany; Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
Trends Mol Med. 2024 Jul;30(7):633-641. doi: 10.1016/j.molmed.2024.04.012. Epub 2024 May 13.
Hormesis is a phenomenon whereby low-level stress can improve cellular, organ, or organismal fitness in response to a subsequent similar or other stress insult. Whereas hormesis is thought to contribute to the fitness benefits arising from symbiotic host-microbe interactions, the putative benefits of hormesis in host-pathogen interactions have yet to be explored. Hormetic responses have nonetheless been reported in experimental models of infection, a common feature of which is regulation of host mitochondrial function. We propose that these mitohormetic responses could be harnessed therapeutically to limit the severity of infectious diseases.
胁迫刺激是一种现象，即低水平的压力可以改善细胞、器官或生物体的适应能力，以应对随后的类似或其他压力损伤。虽然胁迫刺激被认为有助于共生的宿主-微生物相互作用带来的适应性益处，但在宿主-病原体相互作用中，胁迫刺激的假定益处尚未得到探索。然而，在感染的实验模型中已经报道了胁迫刺激反应，其一个共同特征是调节宿主线粒体功能。我们提出，这些线粒体适应反应可以被用于治疗，以限制传染病的严重程度。
