Chehade Mirna, Wright Benjamin L, Walsh Samantha, Bailey Dominique D, Muir Amanda B, Klion Amy D, Collins Margaret H, Davis Carla M, Furuta Glenn T, Gupta Sandeep, Khoury Paneez, Peterson Kathryn A, Jensen Elizabeth T
Departments of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Medicine, Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic Arizona, Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz.
J Allergy Clin Immunol Glob. 2024 Apr 16;3(3):100260. doi: 10.1016/j.jacig.2024.100260. eCollection 2024 Aug.
The demographic characteristics of patients with eosinophilic gastrointestinal diseases (EGIDs) are poorly understood. Population-based assessments of EGID demographics may indicate health disparities in diagnosis.
We aimed to characterize the demographic distribution of EGIDs and evaluate the potential for bias in reporting patient characteristics.
We conducted a systematic review, extracting data on age, sex, gender, race, ethnicity, body mass index, insurance, and urban/rural residence on EGID patients and the source population. Differences in proportions were assessed by chi-square tests. Demographic reporting was compared to recent guidelines.
Among 50 studies that met inclusion/exclusion criteria, 12 reported ≥1 demographic feature in both EGID and source populations. Except for age and sex or gender, demographics were rarely described (race = 4, ethnicity = 1, insurance = 1) or were not described (body mass index, urban/rural residence). A higher proportion of male subjects was observed for EoE or esophageal eosinophilia relative to the source population, but no difference in gender or sex distribution was observed for other EGIDs. "Sex" and "gender" were used interchangeably, and frequently only the male proportion was reported. Reporting of race and ethnicity was inconsistent with guidelines.
Current data support a male predominance for EoE only. Evidence was insufficient to support enrichment of EGIDs in any particular racial, ethnic, or other demographic group. Population-based studies presenting demographics on both cases and source populations are needed. Implementation of guidelines for more inclusive reporting of demographic characteristics is crucial to prevent disparities in timely diagnosis and management of patients with EGIDs.
嗜酸性粒细胞性胃肠疾病（EGID）患者的人口统计学特征尚不清楚。基于人群的EGID人口统计学评估可能表明诊断中的健康差异。
我们旨在描述EGID的人口统计学分布，并评估报告患者特征时存在偏差的可能性。
我们进行了一项系统评价，提取了EGID患者及其来源人群的年龄、性别、种族、民族、体重指数、保险状况以及城乡居住地等数据。通过卡方检验评估比例差异。将人口统计学报告与最新指南进行比较。
在符合纳入/排除标准的50项研究中，有12项报告了EGID人群和来源人群中≥1种人口统计学特征。除年龄和性别外，人口统计学特征很少被描述（种族=4项研究，民族=1项研究，保险状况=1项研究）或未被描述（体重指数、城乡居住地）。与来源人群相比，EoE或食管嗜酸性粒细胞增多症患者中男性比例更高，但其他EGID在性别分布上没有差异。“性别”和“性”被交替使用，且通常只报告了男性比例。种族和民族的报告与指南不一致。
目前的数据仅支持EoE以男性为主。证据不足以支持EGID在任何特定种族、民族或其他人口群体中的富集。需要开展基于人群的研究，报告病例和来源人群的人口统计学特征。实施更全面报告人口统计学特征的指南对于防止EGID患者在及时诊断和管理方面的差异至关重要。
