ICI 35868（丙泊酚）：一种新型静脉麻醉剂。与阿法沙龙的比较。

ICI 35868 (Diprivan): a new intravenous anaesthetic. A comparison with Althesin.

作者信息

Kay B, Stephenson D K

出版信息

Anaesthesia. 1980 Dec;35(12):1182-7. doi: 10.1111/j.1365-2044.1980.tb05075.x.

DOI:10.1111/j.1365-2044.1980.tb05075.x

Abstract

ICI 35868 (Diprivan), 1-2 mg/kg was used to induce anaesthesia in 20 patients, and the results compared with induction of anaesthesia by Althesin 0.5 ml/kg given to a similar group of 20 patients. ICI 35868 was effective in inducing anaesthesia, but produced more respiratory depression, and cardiovascular effects which were significantly different from those produced by Althesin. ICI 35868 gave a smoother induction. It is concluded that ICI 35868 is a promising new induction agent which may also find application for the maintenance of anaesthesia.

摘要

采用1-2毫克/千克的ICI 35868（得普利麻）对20例患者进行麻醉诱导，并将结果与给予相似的20例患者0.5毫升/千克的爱苏威尔麻醉诱导结果进行比较。ICI 35868在诱导麻醉方面有效，但会产生更多的呼吸抑制以及与爱苏威尔产生的心血管效应显著不同的心血管效应。ICI 35868诱导过程更平稳。得出的结论是，ICI 35868是一种有前景的新型诱导剂，也可能适用于麻醉维持。