Rolly G, Versichelen L, Huyghe L, Mungroop H
Br J Anaesth. 1985 Aug;57(8):743-6. doi: 10.1093/bja/57.8.743.
Sixty unpremedicated patients (30 male) were randomly allocated to three groups. They received an induction dose of propofol 2 mg kg-1 over 5, 20 or 60 s to a forearm vein. Anaesthesia was maintained with conventional inhalation anaesthetic agents. Anaesthesia was induced satisfactorily in all 20 of the patients in the 5-s group, in 19 of the patients in the 20-s group and in 18 of the patients in the 60-s group. The rate of injection had a significant influence on induction time. Mean induction time increased from 21.5 to 34.7 and 50.5 s, when injection time was increased from 5 to 20 to 60 s, respectively. Similar induction times were found in male and female patients. There was no significant difference between the groups, in depth of anaesthesia obtained--as assessed by the eyelash reflex. Mean arterial pressure decreased to the same extent in all three groups. Two minutes after induction, mean systolic arterial pressure was reduced by 15.1, 13.5 and 19.3 mm Hg in the 5-, 20- and 60-s groups, respectively, and mean diastolic arterial pressure by 10.3, 13.2 and 13.7 mm Hg. Heart rate changes were insignificant. Apnoea of more than 10 s duration was seen frequently in all three groups, but the results suggest that the incidence was not influenced by the rate of injection. Three patients experienced mild pain at the time of injection. No major adverse reactions occurred during or after anaesthesia.
60例未使用术前药的患者（30例男性）被随机分为三组。他们通过前臂静脉在5秒、20秒或60秒内接受2毫克/千克的异丙酚诱导剂量。使用传统吸入麻醉剂维持麻醉。5秒组的所有20例患者、20秒组的19例患者和60秒组的18例患者麻醉诱导均成功。注射速度对诱导时间有显著影响。当注射时间分别从5秒增加到20秒再增加到60秒时，平均诱导时间从21.5秒增加到34.7秒和50.5秒。男性和女性患者的诱导时间相似。通过睫毛反射评估，各组之间获得的麻醉深度没有显著差异。三组患者的平均动脉压均下降到相同程度。诱导后两分钟，5秒组、20秒组和60秒组的平均收缩压分别降低15.1毫米汞柱、13.5毫米汞柱和19.3毫米汞柱，平均舒张压分别降低10.3毫米汞柱、13.2毫米汞柱和13.7毫米汞柱。心率变化不显著。所有三组中均频繁出现持续超过10秒的呼吸暂停，但结果表明其发生率不受注射速度的影响。三名患者在注射时出现轻度疼痛。麻醉期间或麻醉后未发生重大不良反应。
