De Grood P M, Coenen L G, van Egmond J, Booij L H, Crul J F
Acta Anaesthesiol Scand. 1987 Apr;31(3):219-23. doi: 10.1111/j.1399-6576.1987.tb02554.x.
To provide general anaesthesia with endotracheal intubation during regional blockades, three dose regimens of propofol emulsion were studied: induction 2 mg kg-1, infusion rate 9 mg kg-1 h-1 (Group 1); induction 2.5 mg kg-1, infusion rate 12 mg kg-1 h-1 (Group 2); induction 2.5 mg kg-1, infusion rate 9 mg kg-1 (Group 3). Each group comprised 10 healthy (ASA class 1 or 2) unpremedicated patients. The induction times measured from the start of injection until counting ceased (+/- 50 s) and until eye-lash reflex disappeared (+/- 80 s) showed no statistical differences between groups. In five patients in Group 1 and one patient in each of Groups 2 and 3 the induction dose was too low for intubation. Pain on injection was seen in 13 cases (mild 6, moderate 6 and severe 1). Cough accompanied by hypersalivation was the most important side-effect. Recovery times varied widely and showed no statistical differences. Answering simple questions was possible after 14 min in Group 1, 23 min in Group 2 and 19 min in Group 3. Apart from a short period of euphoria, recovery was uneventful. There was no tendency to fall asleep again. None of the combinations of induction doses and infusion rates provided good anaesthesia conditions for an acceptable number of patients.
为了在区域阻滞期间实施气管插管全身麻醉，研究了丙泊酚乳剂的三种给药方案：诱导剂量2mg/kg，输注速率9mg·kg⁻¹·h⁻¹（第1组）；诱导剂量2.5mg/kg，输注速率12mg·kg⁻¹·h⁻¹（第2组）；诱导剂量2.5mg/kg，输注速率9mg/kg（第3组）。每组包括10例健康（ASA分级1或2级）且未用术前药的患者。从注射开始至计数停止（±50秒）以及至睫毛反射消失（±80秒）测得的诱导时间在各组之间无统计学差异。第1组的5例患者以及第2组和第3组各1例患者的诱导剂量过低，无法进行插管。注射时疼痛见于13例（轻度6例、中度6例和重度1例）。咳嗽伴唾液分泌过多是最重要的副作用。恢复时间差异很大，无统计学差异。第1组在14分钟后、第2组在23分钟后、第3组在19分钟后能够回答简单问题。除了短时间的欣快感外，恢复过程平稳。没有再次入睡的倾向。诱导剂量和输注速率的任何组合都未为可接受数量的患者提供良好的麻醉条件。
