Cummings G C, Dixon J, Kay N H, Windsor J P, Major E, Morgan M, Sear J W, Spence A A, Stephenson D K
Anaesthesia. 1984 Dec;39(12):1168-71. doi: 10.1111/j.1365-2044.1984.tb06425.x.
In order to avoid Cremophor-related reactions and reduce the incidence of pain on injection, diisopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side-effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.
为避免与聚氧乙烯蓖麻油相关的反应并降低注射时疼痛的发生率，二异丙酚（ICI 35868；丙泊酚）已被重新配制成乳剂。115名患者接受了新配方丙泊酚的诱导剂量。在95%的健康、未用术前药的患者中诱导麻醉所需的剂量为2.5毫克/千克。诱导与一定程度的心血管和呼吸抑制有关。尽管有一些轻微的副作用，但没有不良反应。注射时疼痛的发生率较低（3%），92%的患者诱导的总体质量被评估为良好或足够。
