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载药囊泡作为治疗结直肠癌的一种有前途的方法:聚焦于化疗药物和天然产物的递送。

Niosomes as a Promising Therapeutic Approach against Colorectal Cancer: A Focus on the Delivery of Chemotherapeutics and Natural Products.

机构信息

Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Department of Medical Sciences, Faculty of Nursing, Warith Al-Anbiyaa University, Kerbala, Iraq.

出版信息

Curr Pharm Des. 2024;30(21):1659-1666. doi: 10.2174/0113816128303645240429052835.

Abstract

Nanotechnology has emerged as an effective approach to cancer treatment, including Colorectal Cancer (CRC). While conventional treatments, such as chemotherapeutic agents, are used to manage CRC, their efficacy can be improved using drug delivery systems that enhance their bioavailability and reduce side effects. Niosomes, polymeric nanoparticles, have shown promise as biocompatible vehicles that can transport hydrophilic and lipophilic molecules. This can result in reduced drug dosage and increased efficacy. This review examines the use of niosomal formulations as a delivery platform for treating CRC and provides practical insights into their clinical applications.

摘要

纳米技术已成为治疗癌症的有效手段,包括结直肠癌(CRC)。虽然化疗药物等传统疗法被用于治疗 CRC,但通过使用药物递送系统可以提高其疗效,增强其生物利用度并降低副作用。 脂质体和聚合物纳米粒作为生物相容性载体具有很大的应用潜力,可以运输亲水性和疏水性分子。这可以减少药物剂量并提高疗效。本文综述了脂质体制剂作为 CRC 治疗的递药平台的应用,并对其临床应用提供了实用的见解。

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