Izadi Alireza, Paknia Fatemeh, Roostaee Maryam, Mousavi Seyed Amin Ayatollahi, Barani Mahmood
Department of Medical Parasitology and Mycology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Nanotechnology. 2024 May 30;35(33). doi: 10.1088/1361-6528/ad4bed.
, a rapidly emerging multidrug-resistant fungal pathogen, poses a global health threat, with cases reported in over 47 countries. Conventional detection methods struggle, and the increasing resistance ofto antifungal agents has limited treatment options. Nanoparticle-based therapies, utilizing materials like silver, carbon, zinc oxide, titanium dioxide, polymer, and gold, show promise in effectively treating cutaneous candidiasis. This review explores recent advancements in nanoparticle-based therapies, emphasizing their potential to revolutionize antifungal therapy, particularly in combatinginfections. The discussion delves into mechanisms of action, combinations of nanomaterials, and their application against multidrug-resistant fungal pathogens, offering exciting prospects for improved clinical outcomes and reduced mortality rates. The aim is to inspire further research, ushering in a new era in the fight against multidrug-resistant fungal infections, paving the way for more effective and targeted therapeutic interventions.
作为一种迅速出现的多重耐药真菌病原体，对全球健康构成威胁，47 个以上国家都报告了相关病例。传统检测方法面临困难，而且其对抗真菌药物的耐药性不断增加，限制了治疗选择。基于纳米颗粒的疗法，利用银、碳、氧化锌、二氧化钛、聚合物和金等材料，在有效治疗皮肤念珠菌病方面显示出前景。本综述探讨了基于纳米颗粒疗法的最新进展，强调其变革抗真菌治疗的潜力，特别是在对抗感染方面。讨论深入研究了作用机制、纳米材料的组合及其对多重耐药真菌病原体的应用，为改善临床结果和降低死亡率提供了令人兴奋的前景。目的是激发进一步的研究，开创抗击多重耐药真菌感染的新时代，为更有效和有针对性的治疗干预铺平道路。
