Bernstein R M, Pereira R S, Holden A J, Black C M, Howard A, Ansell B M
Ann Rheum Dis. 1985 Aug;44(8):503-6. doi: 10.1136/ard.44.8.503.
The clinical presentation of scleroderma in childhood is even more varied than in adult life. This study of 19 children shows that antinuclear antibodies (ANA) detected on the HEp2 cell substrate are just as common as in the adult disorders. All seven children with diffuse scleroderma or acrosclerosis were ANA positive, as were eight of the 12 with more localised disease. Antinucleolar antibodies were particularly frequent (58% overall), but anticentromere antibody was not observed. Enzyme-linked immunosorbent assays (ELISAs) for antibodies to collagen types I-V, in contrast to adult scleroderma, gave normal results in all childhood cases.
儿童硬皮病的临床表现比成人更为多样。这项对19名儿童的研究表明，在HEp2细胞基质上检测到的抗核抗体（ANA）与成人疾病中的情况一样常见。所有7名患有弥漫性硬皮病或肢端硬化症的儿童ANA均为阳性，12名患有局限性疾病的儿童中有8名也是如此。抗核仁抗体尤为常见（总体为58%），但未观察到抗着丝点抗体。与成人硬皮病不同的是，针对I-V型胶原抗体的酶联免疫吸附测定（ELISA）在所有儿童病例中结果均正常。
