Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA.
Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nat Cell Biol. 2024 May;26(5):674-686. doi: 10.1038/s41556-024-01410-1. Epub 2024 May 16.
Although it is well described that mitochondria are at the epicentre of the energy demands of a cell, it is becoming important to consider how each cell tailors its mitochondrial composition and functions to suit its particular needs beyond ATP production. Here we provide insight into mitochondrial heterogeneity throughout development as well as in tissues with specific energy demands and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling.
尽管线粒体处于细胞能量需求的中心位置已得到充分描述，但考虑每个细胞如何根据其特定需求（超出 ATP 产生）来调整其线粒体组成和功能也变得越来越重要。本文将深入探讨整个发育过程以及具有特定能量需求的组织中的线粒体异质性，并讨论线粒体的可塑性如何有助于细胞命运决定和组织重塑。
