Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China.
J Mater Chem B. 2024 May 29;12(21):5150-5156. doi: 10.1039/d4tb00318g.
Hydrogen sulfide (HS) and hydrazine (NH) are toxic compounds in environmental and living systems, and hydrogen sulfide is also an important signaling molecule. However, in the absence of dual-color probes capable of detecting both HS and NH, the ability to monitor the crosstalk of these substances is restricted. Herein, we developed an ESIPT-based dual-response fluorescent probe (BDM-DNP) for HS and NH detection dually responsive sites. The BDM-DNP possessed absorbing strength in the detection of HS and NH, with a large Stokes shift (156 nm for HS and 108 nm for NH), high selectivity and sensitivity, and good biocompatibility. Furthermore, BDM-DNP can be utilized for the detection of hydrogen sulfide and hydrazine in actual soil, and gaseous HS and NH in environmental systems. Notably, BDM-DNP can detect HS and NH in living cells for disease diagnosis and treatment evaluation.
硫化氢 (HS) 和肼 (NH) 是环境和生命系统中的有毒化合物，而硫化氢也是一种重要的信号分子。然而，在缺乏能够同时检测 HS 和 NH 的双色探针的情况下，监测这些物质相互作用的能力受到限制。在此，我们开发了一种基于 ESIPT 的双响应荧光探针 (BDM-DNP)，用于 HS 和 NH 的检测，具有双响应位点。BDM-DNP 具有检测 HS 和 NH 的吸收强度，Stokes 位移较大（HS 为 156nm，NH 为 108nm），具有高选择性和灵敏度以及良好的生物相容性。此外，BDM-DNP 可用于实际土壤中硫化氢和肼的检测，以及环境系统中气态 HS 和 NH 的检测。值得注意的是，BDM-DNP 可用于检测活细胞中的 HS 和 NH，以进行疾病诊断和治疗评估。
