Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Breast Dis. 2024;43(1):111-118. doi: 10.3233/BD-230057.
Fat transfer has been widely used after breast conservative surgery (BCS) where it aims to recover shapes as a simple, inexpensive, biocompatible method but the technique is not without complications. Platelet Rich Plasma (PRP) is a promising approach to enhance fat graft survival and subsequently improve the outcome. The aim of this study was to evaluate the effect of enriching fat graft with PRP for delayed correction of deformities after conservative surgery for breast cancer regarding esthetic outcome and incidence of complications.
The current study included 50 female patients who were scheduled for delayed lipofilling for correction of deformities after conservative surgery for breast cancer. The studied patients were randomly allocated into 2 groups: Group I (G I) included 25 patients scheduled for PRP enriched lipoinjection and Group II (G II) included 25 patients scheduled for lipoinjection without PRP as a control group.
Number of sessions of lipoinjection was significantly less in G I in comparison to G II (P = 0.024). During the 2nd session; the amounts of fat injected and harvested were significantly less in G I in comparison to G II (P = 0.049 and 0.001 respectively). Recipient site complications were significantly more evident in G II in comparison to G I (P = 0.01). Surgeon and patient satisfactions were significantly more evident in GI in comparison to G II (P = 0.005 and 0.029 respectively).
The addition of PRP to fat grafts is a simple, cost-effective and safe method to improve esthetic outcome and decrease complications.
脂肪转移已广泛应用于保乳手术后（BCS），旨在通过一种简单、廉价、生物相容性好的方法来恢复乳房形状，但该技术并非没有并发症。富血小板血浆（PRP）是一种有前途的方法，可以提高脂肪移植物的存活率，从而改善结果。本研究旨在评估富含 PRP 的脂肪移植在乳腺癌保乳手术后延迟矫正畸形对美容效果和并发症发生率的影响。
本研究纳入了 50 名计划接受延迟脂肪填充以矫正乳腺癌保乳手术后畸形的女性患者。将研究对象随机分为 2 组：第 I 组（G I）包括 25 例计划进行 PRP 强化脂肪注射的患者，第 II 组（G II）包括 25 例计划进行无 PRP 脂肪注射的患者作为对照组。
G I 组脂肪注射次数明显少于 G II 组（P = 0.024）。在第 2 次注射时，G I 组注射和收获的脂肪量明显少于 G II 组（P = 0.049 和 0.001）。G II 组受区并发症明显多于 G I 组（P = 0.01）。G I 组的医生和患者满意度明显高于 G II 组（P = 0.005 和 0.029）。
PRP 脂肪移植是一种简单、经济有效的方法，可以改善美容效果，减少并发症。
