Jensen O L, Gluud B S, Birgens H S
Acta Ophthalmol (Copenh). 1985 Jun;63(3):341-5. doi: 10.1111/j.1755-3768.1985.tb06817.x.
Tear concentration of lactoferrin (LF) was measured by an ELISA technique and followed in 25 patients undergoing cataract surgery. The pre-operative concentration of LF in tears was 773 +/- 60 micrograms/ml (+/- SE) (range: 407-1514 micrograms/ml). On the first day following surgery, there was a significant decrease in tear LF concentration to 377 +/- 45 micrograms/ml followed by a gradual return to the initial value during a post-operative observation period of twelve days. There was an inverse linear relationship between the LF concentration and the tear secretion rate measured by a modified Schirmer I test (1 min) suggesting a constant LF secretion rate by the tear glands. The contribution of LF from neutrophils to the tear fluid seems to be of minor importance. Since LF has known antibacterial and anti-inflammatory effects, our results may contribute to a further understanding of the microbial vulnerability or resistance of the eye following surgical procedures.
采用酶联免疫吸附测定（ELISA）技术检测了25例接受白内障手术患者泪液中乳铁蛋白（LF）的浓度，并进行了跟踪监测。术前泪液中LF的浓度为773±60微克/毫升（±标准误）（范围：407 - 1514微克/毫升）。术后第一天，泪液LF浓度显著下降至377±45微克/毫升，随后在术后12天的观察期内逐渐恢复到初始值。通过改良的Schirmer I试验（1分钟）测得的LF浓度与泪液分泌率之间存在负线性关系，提示泪腺LF分泌率恒定。中性粒细胞产生的LF对泪液的贡献似乎较小。由于LF具有已知的抗菌和抗炎作用，我们的结果可能有助于进一步了解手术后眼部的微生物易感性或抵抗力。
