Jensen O L, Gluud B S, Birgens H S
Acta Ophthalmol (Copenh). 1986 Feb;64(1):83-7. doi: 10.1111/j.1755-3768.1986.tb06877.x.
The tear lactoferrin content and the tear secretion rate was determined in 105 normal subjects (age range: 15-93 years) and 21 diabetic patients (age 21-78 years). Tear sampling was performed using glass capillaries and the lactoferrin concentration in tears was tested employing an enzyme-linked immunosorbent assay. Tear secretion rate was measured using standardized Halberg filter paper placed in the inferior fornix for 5 min. The lactoferrin level of normal tears showed a significant inverse correlation with age, the mean value of the 8th decade (0.81 mg/ml) constituting only about half the value of the lactoferrin level found in the 3rd decade (1.48 mg/ml). The tear secretion rate also displayed a significant decrease with age, but no correlation could be demonstrated between the tear secretion rate and lactoferrin concentration. No difference was found in lactoferrin level between men and women. We were not able to demonstrate any correlation between lactoferrin content of tears and the duration of diabetes in the 21 diabetic subjects, and there was no difference between the level of lactoferrin in normal tears compared to the concentration in diabetic tears. No difference was found between the tear secretion rate in normals and in diabetics.
对105名正常受试者（年龄范围：15 - 93岁）和21名糖尿病患者（年龄21 - 78岁）测定了泪液乳铁蛋白含量和泪液分泌率。使用玻璃毛细管进行泪液采样，并采用酶联免疫吸附测定法检测泪液中的乳铁蛋白浓度。使用置于下穹窿5分钟的标准化哈伯格滤纸测量泪液分泌率。正常泪液的乳铁蛋白水平与年龄呈显著负相关，第八个十年的平均值（0.81毫克/毫升）仅约为第三个十年（1.48毫克/毫升）发现的乳铁蛋白水平值的一半。泪液分泌率也随年龄显著下降，但泪液分泌率与乳铁蛋白浓度之间未显示出相关性。男性和女性的乳铁蛋白水平没有差异。在21名糖尿病受试者中，我们未能证明泪液乳铁蛋白含量与糖尿病病程之间存在任何相关性，并且正常泪液中的乳铁蛋白水平与糖尿病泪液中的浓度相比没有差异。正常人和糖尿病患者的泪液分泌率没有差异。
