Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Trends Endocrinol Metab. 2024 Aug;35(8):677-679. doi: 10.1016/j.tem.2024.05.003. Epub 2024 May 16.
Cardiomyocyte (CM) death drives heart failure worldwide, and efficient CM regeneration remains a fervently pursued but unachieved goal. Ji and colleagues recently described a novel approach to regeneration by orchestrating divergent sphingolipid signaling pathways in CMs and cardiac fibroblasts (CFs). The findings uncover new biology and offer interesting translational opportunities.
心肌细胞（CM）死亡导致全球心力衰竭，而有效的 CM 再生仍然是一个强烈追求但尚未实现的目标。季及其同事最近描述了一种通过协调 CM 和心脏成纤维细胞（CF）中不同的神经酰胺信号通路来实现再生的新方法。这些发现揭示了新的生物学，并提供了有趣的转化机会。
