Antzoulatos Evan G, Miller Earl K
The Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95618, USA.
The Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2014 Jul 2;83(1):216-25. doi: 10.1016/j.neuron.2014.05.005. Epub 2014 Jun 12.
Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition and has been linked to conditions like autism and schizophrenia. We recorded from multiple electrodes in PFC and STR while monkeys acquired new categories. Category learning was accompanied by an increase in beta band synchronization of LFPs between, but not within, the PFC and STR. After learning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the other category, suggesting category-specific functional circuits. This category-specific synchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct monosynaptic connections from the PFC to STR. However, causal connectivity analyses suggested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence. This supports models positing that the basal ganglia "train" the PFC. Category learning may depend on the formation of functional circuits between the PFC and STR.
前额叶皮层（PFC）与纹状体（STR）之间的功能连接被认为对认知至关重要，并且与自闭症和精神分裂症等病症有关。当猴子学习新类别时，我们在前额叶皮层和纹状体的多个电极上进行了记录。类别学习伴随着前额叶皮层和纹状体之间（而非内部）局部场电位（LFP）的β波段同步增加。学习后，不同的前额叶皮层 - 纹状体电极对在某一类别或另一类别上表现出更强的同步性，表明存在类别特异性功能回路。这种类别特异性同步性在前额叶皮层的尖峰信号与纹状体的局部场电位之间也可见，但反之则不然，这反映了从前额叶皮层到纹状体的直接单突触连接。然而，因果连接分析表明，从纹状体到前额叶皮层的多突触连接产生了更强的整体影响。这支持了认为基底神经节“训练”前额叶皮层的模型。类别学习可能依赖于前额叶皮层和纹状体之间功能回路的形成。
