Elias J A, Schreiber A D, Gustilo K, Chien P, Rossman M D, Lammie P J, Daniele R P
J Immunol. 1985 Nov;135(5):3198-204.
The elaboration of interleukin 1 (IL 1) by mononuclear phagocytes is important in the regulation of human inflammatory and fibrotic reactions. Mononuclear phagocytes are morphologically and functionally heterogeneous cells. To further understand the processes controlling inflammation and fibrosis, in particular that in the human lung, we studied the elaboration of IL 1 by unfractionated and density-fractionated human alveolar macrophages and blood monocytes. Stimulated blood monocytes elaborated more IL 1 than stimulated alveolar macrophages. In addition, denser alveolar macrophages and blood monocytes elaborated more IL 1 than less dense alveolar macrophages and monocytes. Lastly, as monocytes matured in vitro, they lost their ability to elaborate IL 1 and became less dense. Thus, there is variability between and within mononuclear phagocyte cell populations in their ability to elaborate IL 1. These differences may result in part from differences in cell maturation.
单核吞噬细胞产生白细胞介素1（IL - 1）在调节人类炎症和纤维化反应中起重要作用。单核吞噬细胞是形态和功能各异的细胞。为了进一步了解控制炎症和纤维化的过程，特别是人类肺部的相关过程，我们研究了未分级和密度分级的人肺泡巨噬细胞及血液单核细胞产生IL - 1的情况。受刺激的血液单核细胞比受刺激的肺泡巨噬细胞产生更多的IL - 1。此外，密度较大的肺泡巨噬细胞和血液单核细胞比密度较小的肺泡巨噬细胞和单核细胞产生更多的IL - 1。最后，单核细胞在体外成熟时，它们产生IL - 1的能力丧失且密度变小。因此，单核吞噬细胞群体之间以及群体内部产生IL - 1的能力存在差异。这些差异可能部分源于细胞成熟度的不同。
