内皮素-1 可刺激人单核细胞体外释放 TNF-α、IL-1β 和 IL-6。
Endothelin-1 stimulates human monocytes in vitro to release TNF-alpha , IL-1beta and IL-6.
机构信息
Department of Anesthesiology Institute of Clinical Medicine University of Tromsø Tromsø N-9038 Norway.
出版信息
Mediators Inflamm. 1993;2(6):417-22. doi: 10.1155/S0962935193000596.
Abstract
Increased plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-alpha, IL-1beta and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-alpha was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses.
摘要
在炎症性疾病期间，血浆和组织中内皮素-1（ET-1）水平升高，表明 ET-1 在炎症反应的病理生理学中起作用。作者研究了 ET-1 对单核细胞和单核细胞衍生的巨噬细胞细胞因子释放的影响。ET-1 以剂量和时间依赖的方式增加 TNF-α、IL-1β 和 IL-6 的分泌。最佳 ET-1 浓度范围为 0.01 至 1 nM。最大反应是细胞因子释放增加 200%至 400%。时程研究表明，ET-1 诱导的细胞因子模式在单核细胞和巨噬细胞中不同，尽管在单核细胞和巨噬细胞上清液中均观察到 TNF-α 的早期增加。总之，ET-1 刺激单核细胞和巨噬细胞释放细胞因子，从而证明 ET-1 在调节炎症反应中具有潜在作用。
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