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L3T4⁺和Lyt-2⁺ T细胞亚群中诱导白细胞介素2反应性的差异需求。

Differential requirements for the induction of interleukin 2 responsiveness in L3T4+ and Lyt-2+ T cell subsets.

作者信息

Erard F, Nabholz M, Dupuy-D'Angeac A, MacDonald H R

出版信息

J Exp Med. 1985 Nov 1;162(5):1738-43. doi: 10.1084/jem.162.5.1738.

DOI:10.1084/jem.162.5.1738
PMID:3877142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187921/
Abstract

Minimal requirements for the induction of interleukin 2 (IL-2) responsiveness in purified subsets of murine T lymphocytes have been investigated. Whereas Lyt-2+ cells could be induced to IL-2-dependent growth by lectin, phorbol ester, or calcium ionophore, none of these stimuli was by itself sufficient for L3T4+ cells. The latter cells could, however, be induced to respond to IL-2 by combinations of lectin plus phorbol ester or ionophore plus phorbol ester (but not lectin plus ionophore). Under optimal conditions, growth of L3T4+ cells (like Lyt-2+ cells) was independent of accessory cells and cell-cell contact.

摘要

对诱导小鼠T淋巴细胞纯化亚群中白细胞介素2（IL-2）反应性的最低要求进行了研究。虽然Lyt-2+细胞可通过凝集素、佛波酯或钙离子载体诱导产生依赖IL-2的生长，但这些刺激单独对L3T4+细胞都不充分。然而，后者细胞可通过凝集素加佛波酯或离子载体加佛波酯（但不是凝集素加离子载体）的组合诱导对IL-2产生反应。在最佳条件下，L3T4+细胞（如Lyt-2+细胞）的生长不依赖辅助细胞和细胞间接触。

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本文引用的文献

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Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.用于确定免疫活性细胞频率的有限稀释分析。I. 数据分析。
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Stimulator cell requirements for allospecific T cell subsets: specialized accessory cells are required to activate helper but not cytolytic T lymphocyte precursors.同种特异性T细胞亚群的刺激细胞需求：激活辅助性T淋巴细胞前体需要特定的辅助细胞，但激活细胞毒性T淋巴细胞前体则不需要。
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