Bounous G, Kongshavn P A
J Nutr. 1985 Nov;115(11):1403-8. doi: 10.1093/jn/115.11.1403.
The effect of 20 g/100 g diet of lactalbumin (L), casein (C), soy (S) and wheat (W) protein on the immune responsiveness of C3H/HeN mice has been investigated by measuring the humoral immune response to the T cell-independent antigen, TNP-Ficoll. The humoral immune response of mice fed the L diet was found to be higher than that of mice fed the C, S and W diets. On the other hand, delayed-type hypersensitivity, and splenic cell mitogen responses to phytohemagglutinin and concanavalin A did not differ among mice fed the various diets. Similarly, the type of diet did not appear to influence host resistance to Salmonella typhimurium. It is postulated that the type of protein in the diet influences directly the intrinsic capacity of the B lymphocytes to respond to an immunogenic stimulus.
通过测量对T细胞非依赖性抗原TNP-菲可的体液免疫反应，研究了日粮中20克/100克乳白蛋白（L）、酪蛋白（C）、大豆（S）和小麦（W）蛋白对C3H/HeN小鼠免疫反应性的影响。发现喂食L日粮的小鼠的体液免疫反应高于喂食C、S和W日粮的小鼠。另一方面，喂食不同日粮的小鼠之间，迟发型超敏反应以及脾细胞对植物血凝素和刀豆球蛋白A的有丝分裂原反应没有差异。同样，日粮类型似乎不影响宿主对鼠伤寒沙门氏菌的抵抗力。据推测，日粮中的蛋白质类型直接影响B淋巴细胞对免疫原性刺激作出反应的内在能力。
