Watad Abdulla, Sharif Kassem, Shoenfeld Yehuda
Department of Medicine 'B'.
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Mediterr J Rheumatol. 2017 Jun 27;28(2):64-69. doi: 10.31138/mjr.28.2.64. eCollection 2017 Jun.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. The disease spectrum is heterogeneous in respect to clinical presentation as well as severity of the clinical manifestations. Adjuvants are included in vaccination formulations for their immunogenic properties. Despite being generally well tolerated, safe and effective, some genetically predisposed individuals can develop generalized non-specific constitutional symptoms, autoantibody production, new onset, or worsening of disease presentation. In this review, we focus on the current knowledge presented in the literature on ASIA syndrome, increasing physician awareness about the basic concepts of ASIA syndrome and highlight the devastating amount of data accumulated in the last few years concerning the relationship between various adjuvants and autoimmunity.
佐剂诱发的自身免疫/炎症综合征（ASIA），也称为肖费尔德综合征，涵盖了几种在接触具有佐剂活性的物质后诱发的自身免疫性疾病/现象。该疾病谱在临床表现以及临床表现的严重程度方面具有异质性。佐剂因其免疫原性特性而被纳入疫苗制剂中。尽管通常耐受性良好、安全有效，但一些具有遗传易感性的个体可能会出现全身性非特异性体质症状、自身抗体产生、疾病新发或病情加重。在本综述中，我们聚焦于文献中关于ASIA综合征的现有知识，提高医生对ASIA综合征基本概念的认识，并强调过去几年积累的有关各种佐剂与自身免疫之间关系的大量数据。
