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Altered Perception of Environmental Volatility During Social Learning in Emerging Psychosis.

作者信息

Hauke Daniel J, Wobmann Michelle, Andreou Christina, Mackintosh Amatya J, de Bock Renate, Karvelis Povilas, Adams Rick A, Sterzer Philipp, Borgwardt Stefan, Roth Volker, Diaconescu Andreea O

机构信息

Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.

Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.

出版信息

Comput Psychiatr. 2024 Feb 7;8(1):1-22. doi: 10.5334/cpsy.95. eCollection 2024.


DOI:10.5334/cpsy.95
PMID:38774429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11104374/
Abstract

Paranoid delusions or unfounded beliefs that others intend to deliberately cause harm are a frequent and burdensome symptom in early psychosis, but their emergence and consolidation still remains opaque. Recent theories suggest that overly precise prediction errors lead to an unstable model of the world providing a breeding ground for delusions. Here, we employ a Bayesian approach to test for such an unstable model of the world and investigate the computational mechanisms underlying emerging paranoia. We modelled behaviour of 18 first-episode psychosis patients (FEP), 19 individuals at clinical high risk for psychosis (CHR-P), and 19 healthy controls (HC) during an advice-taking task designed to probe learning about others' changing intentions. We formulated competing hypotheses comparing the standard Hierarchical Gaussian Filter (HGF), a Bayesian belief updating scheme, with a mean-reverting HGF to model an altered perception of volatility. There was a significant group-by-volatility interaction on advice-taking suggesting that CHR-P and FEP displayed reduced adaptability to environmental volatility. Model comparison favored the standard HGF in HC, but the mean-reverting HGF in CHR-P and FEP in line with perceiving increased volatility, although model attributions in CHR-P were heterogeneous. We observed correlations between perceiving increased volatility and positive symptoms generally as well as with frequency of paranoid delusions specifically. Our results suggest that FEP are characterised by a different computational mechanism - perceiving the environment as increasingly volatile - in line with Bayesian accounts of psychosis. This approach may prove useful to investigate heterogeneity in CHR-P and identify vulnerability for transition to psychosis.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/19d185437e90/cpsy-8-1-95-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/c4bfe89649b5/cpsy-8-1-95-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/0a351d628a6a/cpsy-8-1-95-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/e17177b66d12/cpsy-8-1-95-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/06b32370da81/cpsy-8-1-95-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/95f523a40422/cpsy-8-1-95-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/19d185437e90/cpsy-8-1-95-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/c4bfe89649b5/cpsy-8-1-95-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/0a351d628a6a/cpsy-8-1-95-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/e17177b66d12/cpsy-8-1-95-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/06b32370da81/cpsy-8-1-95-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/95f523a40422/cpsy-8-1-95-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3470/11104374/19d185437e90/cpsy-8-1-95-g6.jpg

相似文献

[1]
Altered Perception of Environmental Volatility During Social Learning in Emerging Psychosis.

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[2]
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[10]
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引用本文的文献

[1]
The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy.

Npj Ment Health Res. 2025-8-31

[2]
Localizing hierarchical prediction errors and precisions during an oddball task with volatility: Computational insights and relationship with psychosocial functioning in healthy individuals.

Imaging Neurosci (Camb). 2025-2-3

[3]
The role of affective states in computational psychiatry.

Int J Neuropsychopharmacol. 2025-8-1

[4]
Beyond reward learning deficits: Exploration-exploitation instability reveals computational heterogeneity in value-based decision making in early psychosis.

medRxiv. 2025-5-1

[5]
Test-retest reliability of behavioral and computational measures of advice taking under volatility.

PLoS One. 2024

[6]
(Mal)adaptive Mentalizing in the Cognitive Hierarchy, and Its Link to Paranoia.

Comput Psychiatr. 2024-9-11

[7]
Exploring the relationship between frequent cannabis use, belief updating under uncertainty and psychotic-like symptoms.

Front Psychiatry. 2024-7-24

[8]
Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework.

Biol Psychiatry Glob Open Sci. 2024-5-13

[9]
D2/D3 dopamine supports the precision of mental state inferences and self-relevance of joint social outcomes.

Nat Ment Health. 2024

[10]
Different learning aberrations relate to delusion-like beliefs with different contents.

Brain. 2024-8-1

本文引用的文献

[1]
Belief Updating in Subclinical and Clinical Delusions.

Schizophr Bull Open. 2022-12-14

[2]
The computational relationship between reinforcement learning, social inference, and paranoia.

PLoS Comput Biol. 2022-7

[3]
Increased Belief Instability in Psychotic Disorders Predicts Treatment Response to Metacognitive Training.

Schizophr Bull. 2022-6-21

[4]
Everything is connected: Inference and attractors in delusions.

Schizophr Res. 2022-7

[5]
Paranoia and belief updating during the COVID-19 crisis.

Nat Hum Behav. 2021-9

[6]
TAPAS: An Open-Source Software Package for Translational Neuromodeling and Computational Psychiatry.

Front Psychiatry. 2021-6-2

[7]
A generative framework for the study of delusions.

Schizophr Res. 2022-7

[8]
Hierarchical Bayesian models of social inference for probing persecutory delusional ideation.

J Abnorm Psychol. 2020-8

[9]
Dopamine manipulations modulate paranoid social inferences in healthy people.

Transl Psychiatry. 2020-7-5

[10]
Paranoia as a deficit in non-social belief updating.

Elife. 2020-5-26

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