万物皆相连:妄想中的推理与吸引子
Everything is connected: Inference and attractors in delusions.
作者信息
Adams Rick A, Vincent Peter, Benrimoh David, Friston Karl J, Parr Thomas
机构信息
Centre for Medical Image Computing, Dept of Computer Science, University College London, 90 High Holborn, London WC1V 6LJ, UK; Max Planck Centre for Computational Psychiatry and Ageing Research, University College London, Russell Square House, 10-12 Russell Square, London WC1B 5EH, UK.
Sainsbury Wellcome Centre, University College London, 25 Howland St, London W1T 4JG, UK.
出版信息
Schizophr Res. 2022 Jul;245:5-22. doi: 10.1016/j.schres.2021.07.032. Epub 2021 Aug 9.
Delusions are, by popular definition, false beliefs that are held with certainty and resistant to contradictory evidence. They seem at odds with the notion that the brain at least approximates Bayesian inference. This is especially the case in schizophrenia, a disorder thought to relate to decreased - rather than increased - certainty in the brain's model of the world. We use an active inference Markov decision process model (a Bayes-optimal decision-making agent) to perform a simple task involving social and non-social inferences. We show that even moderate changes in some model parameters - decreasing confidence in sensory input and increasing confidence in states implied by its own (especially habitual) actions - can lead to delusions as defined above. Incorporating affect in the model increases delusions, specifically in the social domain. The model also reproduces some classic psychological effects, including choice-induced preference change, and an optimism bias in inferences about oneself. A key observation is that no change in a single parameter is both necessary and sufficient for delusions; rather, delusions arise due to conditional dependencies that create 'basins of attraction' which trap Bayesian beliefs. Simulating the effects of antidopaminergic antipsychotics - by reducing the model's confidence in its actions - demonstrates that the model can escape from these attractors, through this synthetic pharmacotherapy.
根据普遍定义,妄想是一种坚信不疑且抗拒矛盾证据的错误信念。它们似乎与大脑至少近似于贝叶斯推理这一概念相矛盾。在精神分裂症中尤其如此,这种疾病被认为与大脑对世界的模型中确定性降低而非增加有关。我们使用一种主动推理马尔可夫决策过程模型(一种贝叶斯最优决策主体)来执行一项涉及社会和非社会推理的简单任务。我们表明,即使某些模型参数发生适度变化——降低对感官输入的信心以及增加对自身(尤其是习惯性)行动所隐含状态的信心——也会导致上述定义的妄想。将情感纳入模型会增加妄想,特别是在社会领域。该模型还重现了一些经典的心理效应,包括选择诱导的偏好变化以及对自身推理中的乐观偏差。一个关键的观察结果是,对于妄想而言,单个参数的变化既不是必要条件也不是充分条件;相反,妄想是由于条件依赖性产生了“吸引盆”,从而困住了贝叶斯信念。通过降低模型对其行动的信心来模拟抗多巴胺能抗精神病药物的效果表明,通过这种合成药物疗法,模型可以从这些吸引子中逃脱。
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