Barcellini W, Sguotti C, Dall'Aglio P, Garelli S, Meroni P L
J Clin Lab Immunol. 1985 Aug;17(4):177-81.
The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mitomycin-C resistant T-cell helper activity and by a Mitomycin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mitomycin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.
研究了T细胞对由商陆丝裂原（PWM）和金黄色葡萄球菌Cowan I型（SAC）诱导的B淋巴细胞免疫球蛋白合成的需求。我们发现，PWM诱导的B细胞活化受绝对耐丝裂霉素C的T细胞辅助活性和对丝裂霉素C敏感的T细胞抑制活性控制。另一方面，SAC诱导的B细胞活化对胸腺的依赖性较小，不受丝裂霉素C处理或照射的T细胞影响。不同的T细胞需求可能是不同反应性B细胞亚群的一种表现。
