用烟草花叶病毒或针对兔独特型的兔抗独特型抗体脉冲处理的小鼠树突状细胞增强抗体反应。
Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.
作者信息
Francotte M, Urbain J
出版信息
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8149-52. doi: 10.1073/pnas.82.23.8149.
Abstract
The role of splenic lymphoid dendritic cells (DC) and macrophages (M phi) from mice in induction of immune responses in vivo has been investigated. Varying numbers of purified DC and M phi pulsed in vitro with tobacco mosaic virus (TMV) or with rabbit antiidiotypic antibodies (Ab2) directed against a private rabbit anti-TMV idiotype were injected back into syngeneic mice. In both systems, DC appeared to strongly enhance the primary and secondary responses to the virus. Optimal responses were obtained with 5 X 10(4) purified DC carrying TMV or rabbit Ab2. In contrast, M phi were less efficient by a factor of at least 100. These results show the potency of lymphoid DC as inducing cells in T-dependent antibody responses in vivo.
摘要
已经研究了来自小鼠的脾淋巴样树突状细胞（DC）和巨噬细胞（M phi）在体内诱导免疫反应中的作用。将不同数量的体外用烟草花叶病毒（TMV）或针对一种兔抗TMV独特型的兔抗独特型抗体（Ab2）脉冲处理的纯化DC和M phi回注到同基因小鼠体内。在这两个系统中，DC似乎都能强烈增强对该病毒的初次和二次反应。用携带TMV或兔Ab2的5×10⁴个纯化DC可获得最佳反应。相比之下，M phi的效率至少低100倍。这些结果表明淋巴样DC作为体内T细胞依赖性抗体反应中的诱导细胞的效力。
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Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.用烟草花叶病毒或针对兔独特型的兔抗独特型抗体脉冲处理的小鼠树突状细胞增强抗体反应。
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