小鼠的独特型操纵：BALB/c小鼠可表达A/J小鼠的交叉反应独特型。
Idiotypic manipulation in mice: BALB/c mice can express the crossreactive idiotype of A/J mice.
作者信息
Moser M, Leo O, Hiernaux J, Urbain J
出版信息
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4474-8. doi: 10.1073/pnas.80.14.4474.
Abstract
The response of A/J mice to arsonate-coupled keyhole limpet hemocyanin is characterized by a crossreactive idiotype (CRIA). CRIA+ antibodies are restricted to the Igh-Ic haplotype and are never expressed in BALB/c mice after immunization with antigen. Studies at the DNA level suggest that the gene encoding the CRIA heavy chain in A/J mice is probably absent in the genome of BALB/c mice. Despite this, using the immunization cascade tool, we have been able to induce the expression of CRIA+ antibodies in BALB/c mice. These studies led to an apparent paradox, whose understanding will provide new insights into the regulatory mechanisms of the immune system. We suggest that clones secreting CRIA-like Igs in BALB/c mice are "somatic variants" that could arise from gene conversion events.
摘要
A/J小鼠对砷酸盐偶联的钥孔戚血蓝蛋白的反应以交叉反应性独特型（CRIA）为特征。CRIA+抗体限于Igh-Ic单倍型，在用抗原免疫后，BALB/c小鼠中从不表达。DNA水平的研究表明，BALB/c小鼠基因组中可能不存在编码A/J小鼠中CRIA重链的基因。尽管如此，使用免疫级联工具，我们已经能够在BALB/c小鼠中诱导CRIA+抗体的表达。这些研究导致了一个明显的悖论，对其理解将为免疫系统的调节机制提供新的见解。我们认为，BALB/c小鼠中分泌CRIA样免疫球蛋白的克隆是可能由基因转换事件产生的“体细胞变体”。
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Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.独特型-抗独特型调节。I. 用结合果聚糖的骨髓瘤蛋白进行免疫会导致自身抗（抗独特型）抗体的出现以及沉默克隆的激活。
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