Francotte M, Urbain J
J Exp Med. 1984 Nov 1;160(5):1485-94. doi: 10.1084/jem.160.5.1485.
Conventional rabbit antiidiotypic antibodies were raised against a private rabbit anti-tobacco mosaic virus (TMV) idiotype. These rabbit antiidiotypic antibodies were covalently coupled to lipopolysaccharide and then injected into BALB/c mice. As compared with controls, these mice, which have never seen the antigen, synthesized anti-TMV antibodies that are strongly idiotypically cross-reactive with the starting rabbit idiotype. Monoclonal anti-TMV antibodies were prepared from these mice. Furthermore, xenogeneic or syngeneic antiidiotypic antibodies, raised against these monoclonal anti-TMV antibodies, recognized specifically the rabbit idiotype. Rabbit antiidiotypic antibodies alone can induce the same effects, but the concentration of anti-TMV antibodies is lower.
常规兔抗独特型抗体是针对一种兔源特异性抗烟草花叶病毒（TMV）独特型产生的。这些兔抗独特型抗体与脂多糖共价偶联，然后注射到BALB/c小鼠体内。与对照组相比，这些从未接触过该抗原的小鼠合成了与起始兔独特型具有强烈独特型交叉反应的抗TMV抗体。从这些小鼠中制备了单克隆抗TMV抗体。此外，针对这些单克隆抗TMV抗体产生的异种或同种抗独特型抗体特异性识别兔独特型。单独的兔抗独特型抗体也能诱导相同的效应，但抗TMV抗体的浓度较低。
