对来自一只小鼠的抗烟草花叶病毒单克隆抗体的独特型研究。
Idiotypic studies of monoclonal anti-tobacco mosaic virus antibodies from one mouse.
作者信息
Slaoui M, Franssen J D, Hérion P, Urbain J
出版信息
Mol Immunol. 1983 Oct;20(10):1073-80. doi: 10.1016/0161-5890(83)90115-3.
Monoclonal antibodies have been prepared from one BALB/c mouse immunized with tobacco mosaic virus. The monoclonal antibodies are distributed into three subgroups recognizing different epitopes on tobacco mosaic virus subunits. The idiotypic specificities of these monoclonal antibodies have been studied using syngeneic antiidiotypic sera. A sharing of idiotypic specificities has been observed between members of each subset. These idiotypes are not recurrent in BALB/c mice immunized with tobacco mosaic virus.
用烟草花叶病毒免疫一只BALB/c小鼠后制备了单克隆抗体。这些单克隆抗体被分为三个亚组，它们识别烟草花叶病毒亚基上不同的表位。利用同基因抗独特型血清研究了这些单克隆抗体的独特型特异性。在每个亚组的成员之间观察到独特型特异性的共享。在用烟草花叶病毒免疫的BALB/c小鼠中，这些独特型不会重复出现。
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