Zhang Weijie, Zhang Bing, Wang Yihu, Cao Xiaofeng, Wang Jianing, Lu Weipeng, Guo Yanchuan
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Gels. 2024 May 7;10(5):318. doi: 10.3390/gels10050318.
Hydrogels with adhesion properties and a wetted structure are promising alternatives to traditional wound dressing materials. The insufficiency of gelatin hydrogels in terms of their adhesive and mechanical strength limits their application in wound dressings. This work presents the design and preparation of a gelatin-based hydrogel functionalized with dopamine (DA) and layered double hydroxide (LDH). The combination of DA and LDH improves the hydrogel's adhesion properties in terms of interfacial adhesion and inner cohesion. Hydrogels with 8% DA and 4% LDH attained the highest adhesion strength of 266.5 kPa, which increased to 295.5 and 343.3 kPa after hydrophobically modifying the gelatin with octanoyl and decanoyl aldehydes, respectively. The gelatin-based hydrogels also demonstrated a macroporous structure, excellent biocompatibility, and a good anti-inflammatory effect. The developed hydrogels accelerated wound healing in Sprague Dawley rat skin full-thickness wound models.
具有粘附特性和湿润结构的水凝胶是传统伤口敷料材料的有前途的替代品。明胶水凝胶在粘附力和机械强度方面的不足限制了它们在伤口敷料中的应用。这项工作展示了一种用多巴胺（DA）和层状双氢氧化物（LDH）功能化的明胶水凝胶的设计与制备。DA和LDH的组合在界面粘附和内聚方面改善了水凝胶的粘附性能。含有8% DA和4% LDH的水凝胶达到了266.5 kPa的最高粘附强度，在用辛酰醛和癸酰醛对明胶进行疏水改性后，分别增加到295.5 kPa和343.3 kPa。基于明胶的水凝胶还表现出大孔结构、优异的生物相容性和良好的抗炎效果。所开发的水凝胶在斯普拉格-道利大鼠皮肤全层伤口模型中加速了伤口愈合。
