• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

具有可切换形态的水凝胶超软磁性微型机器人的双模态运动

Double-Modal Locomotion of a Hydrogel Ultra-Soft Magnetic Miniature Robot with Switchable Forms.

作者信息

Zhong Shihao, Xin Zhengyuan, Hou Yaozhen, Li Yang, Huang Hen-Wei, Sun Tao, Shi Qing, Wang Huaping

机构信息

Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Peking University First Hospital, Beijing 100034, China.

出版信息

Cyborg Bionic Syst. 2024 Jan 8;6:0077. doi: 10.34133/cbsystems.0077. eCollection 2024.

DOI:10.34133/cbsystems.0077
PMID:38435709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10907021/
Abstract

Flexible miniature robots are expected to enter difficult-to-reach areas in vivo to carry out targeted operations, attracting widespread attention. However, it is challenging for the existing soft miniature robots to substantially alter their stable shape once the structure is designed. This limitation leads to a fixed motion mode, which subsequently restricts their operating environment. In this study, we designed a biocompatible flexible miniature robot with a variable stable form that is capable of adapting to complex terrain environments through multiple movement modes. Inspired by the reversible stretching reaction of alginate saline gel stimulated by changes in environmental ion concentration, we manufactured a morphologically changeable super-soft hydrogel miniature robot body. According to the stretch and contraction shapes of the flexible hydrogel miniature robot, we designed magnetic fields for swing and rolling motion modes to realize multi-shape movement. The experimental results demonstrate that the deflection angle of the designed flexible miniature robot is reversible and can reach a maximum of 180°. The flexible miniature robot can complete forward swinging in the bar stretch state and tumbling motion in the spherical state. We anticipate that flexible hydrogel miniature robots with multiple morphologies and multimodal motion have great potential for biomedical applications in complex, unstructured, and enclosed living environments.

摘要

柔性微型机器人有望进入体内难以到达的区域进行靶向操作,这引起了广泛关注。然而,对于现有的软微型机器人来说,一旦结构设计完成,要大幅改变其稳定形状具有挑战性。这种限制导致了固定的运动模式,进而限制了它们的操作环境。在本研究中,我们设计了一种具有可变稳定形态的生物相容性柔性微型机器人,它能够通过多种运动模式适应复杂的地形环境。受环境离子浓度变化刺激的海藻酸盐盐水凝胶可逆拉伸反应的启发,我们制造了一种形态可变的超软水凝胶微型机器人主体。根据柔性水凝胶微型机器人的伸缩形状,我们设计了用于摆动和滚动运动模式的磁场,以实现多形状运动。实验结果表明,所设计的柔性微型机器人的偏转角是可逆的,最大可达180°。柔性微型机器人可以在杆状拉伸状态下完成向前摆动,在球状状态下完成翻滚运动。我们预计,具有多种形态和多模态运动的柔性水凝胶微型机器人在复杂、非结构化和封闭的生活环境中的生物医学应用具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/131e53c26321/cbsystems.0077.fig.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/a143166845d0/cbsystems.0077.fig.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/3807ffad7b45/cbsystems.0077.fig.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/4e36fdaeb63d/cbsystems.0077.fig.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/e64e00a87f60/cbsystems.0077.fig.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/52b2138a5260/cbsystems.0077.fig.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/55157421cb7c/cbsystems.0077.fig.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/947de77ee6a3/cbsystems.0077.fig.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/8f81fa17a126/cbsystems.0077.fig.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/682bfa8ec686/cbsystems.0077.fig.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/54a5ac2d1ae0/cbsystems.0077.fig.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/131e53c26321/cbsystems.0077.fig.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/a143166845d0/cbsystems.0077.fig.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/3807ffad7b45/cbsystems.0077.fig.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/4e36fdaeb63d/cbsystems.0077.fig.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/e64e00a87f60/cbsystems.0077.fig.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/52b2138a5260/cbsystems.0077.fig.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/55157421cb7c/cbsystems.0077.fig.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/947de77ee6a3/cbsystems.0077.fig.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/8f81fa17a126/cbsystems.0077.fig.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/682bfa8ec686/cbsystems.0077.fig.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/54a5ac2d1ae0/cbsystems.0077.fig.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c25/10907021/131e53c26321/cbsystems.0077.fig.011.jpg

相似文献

1
Double-Modal Locomotion of a Hydrogel Ultra-Soft Magnetic Miniature Robot with Switchable Forms.具有可切换形态的水凝胶超软磁性微型机器人的双模态运动
Cyborg Bionic Syst. 2024 Jan 8;6:0077. doi: 10.34133/cbsystems.0077. eCollection 2024.
2
Biodegradable Magnetic Hydrogel Robot with Multimodal Locomotion for Targeted Cargo Delivery.具有多模态运动的可生物降解磁性水凝胶机器人,用于靶向货物输送。
ACS Appl Mater Interfaces. 2023 Jun 21;15(24):28922-28932. doi: 10.1021/acsami.3c02703. Epub 2023 Jun 7.
3
An Insect-Inspired Terrains-Adaptive Soft Millirobot with Multimodal Locomotion and Transportation Capability.一种具有多模态运动和运输能力的受昆虫启发的地形自适应软微型机器人。
Micromachines (Basel). 2022 Sep 22;13(10):1578. doi: 10.3390/mi13101578.
4
Magnetic-actuated hydrogel microrobots with multimodal motion and collective behavior.磁驱动水凝胶微机器人的多模态运动和群体行为。
J Mater Chem B. 2024 Jul 31;12(30):7440-7449. doi: 10.1039/d4tb00520a.
5
Visible Light-Driven Jellyfish-like Miniature Swimming Soft Robot.可见光驱动的水母状微型游泳软体机器人。
ACS Appl Mater Interfaces. 2021 Oct 6;13(39):47147-47154. doi: 10.1021/acsami.1c13975. Epub 2021 Aug 26.
6
A magnetic multi-layer soft robot for on-demand targeted adhesion.一种用于按需靶向附着的磁性多层软体机器人。
Nat Commun. 2024 Jan 20;15(1):644. doi: 10.1038/s41467-024-44995-9.
7
An Amphibious Fully-Soft Centimeter-Scale Miniature Crawling Robot Powered by Electrohydraulic Fluid Kinetic Energy.一种由电液压流体动能驱动的两栖全软厘米级微型爬行机器人。
Adv Sci (Weinh). 2024 Apr;11(14):e2308033. doi: 10.1002/advs.202308033. Epub 2024 Feb 1.
8
Scale-reconfigurable miniature ferrofluidic robots for negotiating sharply variable spaces.用于在急剧变化空间中通行的可重新配置尺度的微型铁磁流体机器人。
Sci Adv. 2022 Sep 16;8(37):eabq1677. doi: 10.1126/sciadv.abq1677.
9
Gait and locomotion analysis of a soft-hybrid multi-legged modular miniature robot.软杂交多足模块化微型机器人的步态和运动分析。
Bioinspir Biomim. 2021 Sep 28;16(6). doi: 10.1088/1748-3190/ac245e.
10
Miniature Amphibious Robot Actuated by Rigid-Flexible Hybrid Vibration Modules.微型水陆两栖机器人由刚柔混合振动模块驱动。
Adv Sci (Weinh). 2022 Oct;9(29):e2203054. doi: 10.1002/advs.202203054. Epub 2022 Aug 18.

引用本文的文献

1
A Soft Reconfigurable Inverted Climbing Robot Based on Magneto-Elastica-Reinforced Elastomer.一种基于磁弹性增强弹性体的软可重构倒立攀爬机器人。
Micromachines (Basel). 2025 Jul 25;16(8):855. doi: 10.3390/mi16080855.
2
A Magnetically Transformable Twisting Millirobot for Cargo Delivery at Low Reynolds Number.一种用于低雷诺数下货物输送的磁可变形扭转微型机器人。
Adv Intell Syst. 2025 Aug;7(8):2401028. doi: 10.1002/aisy.202401028. Epub 2025 May 19.
3
Hydrogels in Veterinary Vaccine Development: Types, Mechanisms, and Applications.

本文引用的文献

1
A Robot Motion Learning Method Using Broad Learning System Verified by Small-Scale Fish-Like Robot.一种基于广义学习系统的机器人运动学习方法,经小型类鱼机器人验证
IEEE Trans Cybern. 2023 Sep;53(9):6053-6065. doi: 10.1109/TCYB.2023.3269773. Epub 2023 Aug 17.
2
Ultrafast Miniature Robotic Swimmers with Upstream Motility.具有上游运动能力的超快微型机器人游泳器。
Cyborg Bionic Syst. 2023;4:0015. doi: 10.34133/cbsystems.0015. Epub 2023 Mar 15.
3
Multimodal Locomotion and Cargo Transportation of Magnetically Actuated Quadruped Soft Microrobots.
兽医疫苗开发中的水凝胶:类型、作用机制及应用
Gels. 2025 Jun 18;11(6):468. doi: 10.3390/gels11060468.
4
Template-free 3D programmable magnetization of soft millirobots induced by interlayer stress.层间应力诱导的软微型机器人无模板三维可编程磁化
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2426846122. doi: 10.1073/pnas.2426846122. Epub 2025 Jun 4.
5
Multifunctional Janus Hydrogels: Surface Design Strategies for Next-Generation Clinical Solutions.多功能Janus水凝胶:下一代临床解决方案的表面设计策略
Gels. 2025 May 6;11(5):343. doi: 10.3390/gels11050343.
6
In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation.更昔洛韦原位凝胶眼部给药系统的体内和体外研究
BMC Pharmacol Toxicol. 2025 May 13;26(1):102. doi: 10.1186/s40360-025-00934-y.
7
A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023.2003年至2023年原位凝胶给药系统研究进展的文献计量分析与系统评价
Pharmaceutics. 2025 Apr 1;17(4):451. doi: 10.3390/pharmaceutics17040451.
8
Crosslinking a nanocomposite by zirconium sulfate to synthesize a high-durable new-generation polymer gel.通过硫酸锆交联纳米复合材料以合成高耐久性的新一代聚合物凝胶。
Sci Rep. 2025 Apr 3;15(1):11471. doi: 10.1038/s41598-025-92382-1.
9
Magnetic Shaftless Propeller Millirobot with Multimodal Motion for Small-Scale Fluidic Manipulation.用于小规模流体操作的具有多模态运动的磁无轴螺旋桨微型机器人。
Cyborg Bionic Syst. 2025 Mar 12;6:0235. doi: 10.34133/cbsystems.0235. eCollection 2025.
10
Enzymatically Cross-Linked Hydrogel Beads Based on a Novel Poly(aspartamide) Derivative.基于新型聚(天冬酰胺)衍生物的酶促交联水凝胶珠
Gels. 2025 Jan 26;11(2):93. doi: 10.3390/gels11020093.
磁驱动四足软微机器人的多模态运动与货物运输
Cyborg Bionic Syst. 2022;2022:0004. doi: 10.34133/cbsystems.0004. Epub 2022 Dec 30.
4
Programmable aniso-electrodeposited modular hydrogel microrobots.可编程各向异性电沉积模块化水凝胶微机器人。
Sci Adv. 2022 Dec 14;8(50):eade6135. doi: 10.1126/sciadv.ade6135.
5
POMDP-Based Real-Time Path Planning for Manipulation of Multiple Microparticles via Optoelectronic Tweezers.基于部分可观测马尔可夫决策过程的光镊操控多个微粒的实时路径规划
Cyborg Bionic Syst. 2022 Nov 2;2022:9890607. doi: 10.34133/2022/9890607. eCollection 2022.
6
Spinning-enabled wireless amphibious origami millirobot.带旋转功能的无线水陆两栖折纸毫机器人。
Nat Commun. 2022 Jun 14;13(1):3118. doi: 10.1038/s41467-022-30802-w.
7
A Learning-Based Stable Servo Control Strategy Using Broad Learning System Applied for Microrobotic Control.基于广义回归神经网络的微机器人稳定伺服控制策略
IEEE Trans Cybern. 2022 Dec;52(12):13727-13737. doi: 10.1109/TCYB.2021.3121080. Epub 2022 Nov 18.
8
Ionic shape-morphing microrobotic end-effectors for environmentally adaptive targeting, releasing, and sampling.用于环境自适应靶向、释放和采样的离子形状变形微机器人末端执行器。
Nat Commun. 2021 Jan 18;12(1):411. doi: 10.1038/s41467-020-20697-w.
9
Engineering microrobots for targeted cancer therapies from a medical perspective.从医学角度出发,设计用于癌症靶向治疗的微型机器人。
Nat Commun. 2020 Nov 5;11(1):5618. doi: 10.1038/s41467-020-19322-7.
10
Elucidating the interaction dynamics between microswimmer body and immune system for medical microrobots.阐明医疗微型机器人的微型游动体与免疫系统之间的相互作用动态。
Sci Robot. 2020 Jun 17;5(43). doi: 10.1126/scirobotics.aaz3867.