佐剂诱导性关节炎大鼠中自身抗体的证据。

Evidence of autoantibodies in rats with adjuvant-induced arthritis.

作者信息

Castell M, Castellote M C, Queralt J, Barberá G, Torralba A

出版信息

Allergol Immunopathol (Madr). 1985 Sep-Oct;13(5):399-403.

Abstract

The adjuvant arthritis, induced by subdermal injection of heat-killed mycobacteria dispersed in oil, is a form of chronic arthritis in rats. In this paper, the production of autoantibodies against immunoglobulins in rats with adjuvant arthritis was examined by means of the latex agglutination technique. A significant agglutination titre was found in arthritic rats on day 14 of induction and these values decreased throughout the studied period. The positive results in arthritic animals were 100, 86, 86, 29 and 29% on 14, 21, 28, 35 and 42 day after the induction, respectively. These results were significantly higher than those found in control animals. Correlation between latex titre and adjuvant-induced systemic swelling was observed. Treatment with benoxaprofen from day 14, produced a decrease in the latex titre and the values reached normal levels after two weeks of treatment.

摘要

通过皮下注射分散在油中的热灭活分枝杆菌诱导的佐剂性关节炎是大鼠慢性关节炎的一种形式。在本文中，采用乳胶凝集技术检测了佐剂性关节炎大鼠体内抗免疫球蛋白自身抗体的产生情况。在诱导后第14天，关节炎大鼠出现了显著的凝集效价，且在整个研究期间这些值均下降。诱导后第14、21、28、35和42天，关节炎动物的阳性结果分别为100%、86%、86%、29%和29%。这些结果显著高于对照动物。观察到乳胶效价与佐剂诱导的全身肿胀之间存在相关性。从第14天开始用贝诺洛芬治疗，乳胶效价降低，治疗两周后值恢复到正常水平。