Redfern N, Stafford M A, Hull C J
Br J Anaesth. 1985 Dec;57(12):1178-82. doi: 10.1093/bja/57.12.1178.
Propofol was used to induce and maintain anaesthesia in patients undergoing minor gynaecological procedures. Quality of anaesthesia, the rate of recovery and the influence of different methods of premedication were assessed. Unpremedicated patients required a higher induction dose than those premedicated with either lorazepam or papaveretum and hyoscine, but maintenance dose requirements were comparable. Regardless of premedication, there were similar decreases in mean arterial pressure, although respiratory function recovered more rapidly in patients premedicated with lorazepam. No significant changes in heart rate were noted in any group. The overall incidence of pain on injection was 3.7% (lignocaine 0.5 mg added to each 9.5 mg of propofol) and a skin rash occurred in 6% of patients. All patients recovered rapidly and uneventfully.
丙泊酚用于接受小型妇科手术患者的麻醉诱导和维持。评估了麻醉质量、恢复速度以及不同术前用药方法的影响。未进行术前用药的患者诱导剂量高于使用劳拉西泮或哌替啶与东莨菪碱进行术前用药的患者，但维持剂量需求相当。无论术前用药情况如何，平均动脉压均有类似程度的下降，不过使用劳拉西泮进行术前用药的患者呼吸功能恢复得更快。任何组均未观察到心率有显著变化。注射时疼痛的总体发生率为3.7%（每9.5毫克丙泊酚中添加0.5毫克利多卡因），6%的患者出现皮疹。所有患者均迅速且平稳地恢复。
