Bystryn J C, Orentreich N, Stengel F
J Invest Dermatol. 1979 Nov;73(5):317-20. doi: 10.1111/1523-1747.ep12549703.
Direct immunofluroescence studies were performed on hairy and alopecic areas of scalp in patients with alopecia areata, alopecia totalis and male pattern alopecia. Abnormal deposits of C3 and occasionally of IgG and IgM were found in 92% of 12 patients with alopecia areata and in 21% of patients with male pattern alopecia. No abnormalities were seen in 4 patients with alopecia totalis. In both alopecia areata and male pattern alopecia, the deposits were most common along the basement zone of the inferior segment of hair follicles and occurred with equal frequency in alopecic and normal scalp. These observations suggest that immune factors may play a role in the pathogenesis of alopecia areata.
对斑秃、全秃和男性型脱发患者头皮的有毛区和无毛区进行了直接免疫荧光研究。在12例斑秃患者中的92%以及男性型脱发患者中的21%发现了C3异常沉积，偶尔还有IgG和IgM异常沉积。4例全秃患者未发现异常。在斑秃和男性型脱发中，沉积物最常见于毛囊下段的基底区，在无毛头皮和正常头皮中出现的频率相同。这些观察结果表明，免疫因素可能在斑秃的发病机制中起作用。
