Suppr
超能文献

miR-5682 与放疗男性喉癌患者营养状况的关系。

The Relationship between miR-5682 and Nutritional Status of Radiotherapy-Treated Male Laryngeal Cancer Patients.

机构信息

Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-059 Lublin, Poland.

Department of Radiotherapy, St. John of Dukla Lublin Region Cancer Center, 20-090 Lublin, Poland.

出版信息

Genes (Basel). 2024 Apr 27;15(5):556. doi: 10.3390/genes15050556.

DOI:10.3390/genes15050556

PMID:38790185

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11120884/

Abstract

BACKGROUND

Nutritional deficiencies are frequently observed in patients with head and neck cancer (HNC) undergoing radiation therapy. microRNAs (miRNAs) were found to play an important role in the development of metabolic disorders throughout regulation of genes involved in inflammatory responses. This study aimed to explore the correlation between pre-treatment miR-5682 expression and parameters reflecting nutritional deficits in laryngeal cancer (LC) patients subjected to radiotherapy (RT).

METHODS

Expression of miR-5682 was analyzed in plasma samples of 56 male LC individuals. Nutritional status of LC patients was assessed using anthropometric and laboratory parameters, bioelectrical impedance analysis (BIA) and clinical questionnaires.

RESULTS

A high expression of miR-5682 was associated with significantly lower values of BMI, fat mass, fat-free mass and plasma albumin at selected periods of RT course. miR-5682 allowed us to distinguish between patients classified with both SGA-C and low albumin level from other LC patients with 100% sensitivity and 69.6% specificity (AUC = 0.820; < 0.0001). Higher expression of studied miRNA was significantly associated with shorter median overall survival (OS) in LC patients (HR = 2.26; = 0.008).

CONCLUSIONS

analysis of miR-5682 expression demonstrates a potential clinical utility in selection of LC patients suffering from nutritional deficiencies developing as a consequence of RT-based therapy.

摘要

背景

接受放射治疗的头颈部癌症（HNC）患者经常出现营养缺乏。 microRNAs（miRNAs）在代谢紊乱的发展中起着重要作用，通过调节参与炎症反应的基因。本研究旨在探讨放射治疗前 miR-5682 表达与反映喉癌（LC）患者放射治疗（RT）后营养不足参数之间的相关性。

方法

分析了 56 名男性 LC 个体血浆样本中的 miR-5682 表达。使用人体测量和实验室参数、生物电阻抗分析（BIA）和临床问卷评估 LC 患者的营养状况。

结果

miR-5682 高表达与 RT 过程中选定时期 BMI、体脂肪量、去脂体重和血浆白蛋白值显著降低有关。miR-5682 能够以 100%的灵敏度和 69.6%的特异性（AUC = 0.820； < 0.0001）区分 SGA-C 和低白蛋白水平的患者与其他 LC 患者。研究 miRNA 的高表达与 LC 患者的中位总生存期（OS）显著相关（HR = 2.26； = 0.008）。