Liu Huawei, Liu Xinyu, Liu Haiyang, Tang Jiaqi, He Wei, Xu Tianqi, Cheng Baojing, Shi Baoming, Han Jianchun
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
National Soybean Engineering Technology Research Center, Heilongjiang Academy of Green Food Science, Northeast Agricultural University, Harbin 150028, China.
Microorganisms. 2024 May 17;12(5):1012. doi: 10.3390/microorganisms12051012.
Previous studies on the early interference of gut microbiota by () in weaned piglets are rarely reported, and the present trial is a preliminary study. This experiment was conducted to investigate the effects of supplementation on the growth performance, serum biochemistry, immune response, fecal short-chain fatty acids and microbiota of weaned piglets. Sixty weaned piglets were randomly divided into a control group (CON) and a group (BS), which were fed a basal diet and the basal diet supplemented with 5 × 10 CFU per kg, respectively. Each group had 3 replicates and 10 piglets per replicate. The trial lasted for 28 days. The results showed that significantly increased the serum growth hormone (GH) and insulin-like growth factor (IGF) in piglets. Compared with the CON group, the levels of serum immunoglobulin and inflammatory factors in the BS group were significantly improved. In addition, the serum concentrations of zonulin and endotoxin (ET) in the BS group were lower. The dietary addition of significantly increased fecal short-chain fatty acid (SCFA) levels in piglets. Notably, improved the microbial composition by increasing beneficial genera, including , and , and decreasing pathogenic genera, including , and , in piglet feces. Correlation analysis showed that the benefits of dietary supplementation were closely related to its improved microbial composition. In summary, the addition of can improve the immunity function, inflammatory response, gut permeability and SCFA levels of weaned piglets, which may be achieved through the improvement of their microbiota.
此前关于（）对断奶仔猪肠道微生物群早期干预的研究鲜有报道，本试验是一项初步研究。本实验旨在研究添加（）对断奶仔猪生长性能、血清生化指标、免疫反应、粪便短链脂肪酸和微生物群的影响。60头断奶仔猪随机分为对照组（CON）和（）组（BS），分别饲喂基础日粮和每千克基础日粮添加5×10CFU（）的日粮。每组有3个重复，每个重复10头仔猪。试验持续28天。结果表明，（）显著提高了仔猪血清生长激素（GH）和胰岛素样生长因子（IGF）水平。与CON组相比，BS组血清免疫球蛋白和炎症因子水平显著提高。此外，BS组血清中闭合蛋白和内毒素（ET）浓度较低。日粮中添加（）显著提高了仔猪粪便短链脂肪酸（SCFA）水平。值得注意的是，（）通过增加有益菌属，包括（）、（）和（），减少致病菌属，包括（）、（）和（），改善了仔猪粪便中的微生物组成。相关性分析表明，日粮添加（）的益处与其改善的微生物组成密切相关。综上所述，添加（）可以提高断奶仔猪的免疫功能、炎症反应、肠道通透性和SCFA水平，这可能是通过改善其微生物群实现的。
