Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China.
Nutrients. 2024 May 15;16(10):1497. doi: 10.3390/nu16101497.
Maintaining the balance and stability of the gut microbiota is crucial for the gut health and growth development of humans and animals. () has been reported to be beneficial to the gut health of humans and animals, whereas the probiotic effects of a new strain, HD173, remain uncertain. In this study, nursery piglets were utilized as animal models to investigate the extensive impact of HD173 on gut microbiota, metabolites, and host health. The major findings were that this probiotic enhanced the growth performance and improved the health status of the nursery piglets. Specifically, it reduced the level of pro-inflammatory cytokines IL-1β and TNF-α in the serum while increasing the level of IL-10 and SOD. In the gut, HD173 reduced the abundance of pathogenic bacteria such as , , and , while it increased the abundance of butyrate-producing bacteria, including , , and , leading to an enhanced production of butyric acid. Furthermore, HD173 effectively improved the gut metabolic status, enabling the gut microbiota to provide the host with stronger metabolic abilities for nutrients. In summary, these findings provide scientific evidence for the utilization of HD173 in the development and production of probiotic products for maintaining gut health in humans and animals.
维持肠道微生物群的平衡和稳定对人类和动物的肠道健康和生长发育至关重要。（）已被报道对人类和动物的肠道健康有益，而新型菌株 HD173 的益生菌作用尚不确定。在本研究中，仔猪被用作动物模型，以研究 HD173 对肠道微生物群、代谢物和宿主健康的广泛影响。主要发现是，这种益生菌增强了仔猪的生长性能，改善了仔猪的健康状况。具体而言，它降低了血清中促炎细胞因子 IL-1β 和 TNF-α 的水平，同时增加了 IL-10 和 SOD 的水平。在肠道中，HD173 减少了致病性细菌如（）、（）和（）的丰度，而增加了丁酸产生菌的丰度，包括（）、（）和（），导致丁酸产量增加。此外，HD173 有效地改善了肠道代谢状态，使肠道微生物群能够为宿主提供更强的营养代谢能力。总之，这些发现为在人类和动物中开发和生产益生菌产品以维持肠道健康方面利用 HD173 提供了科学依据。
