State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Nano. 2024 Jun 11;18(23):15114-15129. doi: 10.1021/acsnano.4c02605. Epub 2024 May 27.
Implant-related secondary infections are a challenging clinical problem. Sonodynamic therapy (SDT) strategies are promising for secondary biofilm infections by nonsurgical therapy. However, the inefficiency of SDT in existing acoustic sensitization systems limits its application. Therefore, we take inspiration from popular metamaterials and propose the design idea of a metainterface heterostructure to improve SDT efficiency. The metainterfacial heterostructure is defined as a periodic arrangement of heterointerface monoclonal cells that amplify the intrinsic properties of the heterointerface. Herein, we develop a TiO/TiO/vertical graphene metainterface heterostructure film on titanium implants. This metainterface heterostructure exhibits extraordinary sonodynamic and acoustic-to-thermal conversion effects under low-intensity ultrasound. The modulation mechanisms of the metainterface for electron accumulation and separation are revealed. The synergistic sonodynamic/mild sonothermal therapy disrupts biofilm infections (antibacterial rates: 99.99% for , 99.54% for ), and the osseointegration ability of implants is significantly improved in tests. Such a metainterface heterostructure film lays the foundation for the metainterface of manipulating electron transport to enhance the catalytic performance and holding promise for addressing secondary biofilm infections.
植入物相关的继发性感染是一个具有挑战性的临床问题。声动力学疗法（SDT）策略通过非手术治疗对继发性生物膜感染具有很大的应用潜力。然而，现有声敏化系统中 SDT 的效率低下限制了其应用。因此，我们从流行的超材料中汲取灵感，提出了金属界面异质结构的设计思想，以提高 SDT 的效率。金属界面异质结构被定义为异质界面单克隆细胞的周期性排列，可增强异质界面的固有特性。在此，我们在钛植入物上开发了 TiO/TiO/垂直石墨烯金属界面异质结构薄膜。该金属界面异质结构在低强度超声下表现出非凡的声动力学和声致热转换效应。揭示了金属界面的电子积累和分离调制机制。协同声动力学/温和声热疗法破坏生物膜感染（抗菌率： ， ），并在 测试中显著提高了植入物的骨整合能力。这种金属界面异质结构薄膜为操纵电子输运以增强催化性能的金属界面奠定了基础，为解决继发性生物膜感染提供了新的思路。
