Rauf Sameer Abdul, Shah Hussain Haider, Khatri Rahul, Ul Haq Mansoor, Dave Tirth, Ali Javaria Parwez, Ali Syed Khizar
Department of Internal Medicine Liaquat National Hospital and Medical College Karachi Pakistan.
Department of Internal Medicine Dow University of Health Sciences Karachi Pakistan.
Clin Case Rep. 2024 May 24;12(6):e8978. doi: 10.1002/ccr3.8978. eCollection 2024 Jun.
This case highlights the importance of considering tuberculosis as an underlying cause of gastrointestinal amyloidosis, even in patients previously treated for the infection. Clinicians should maintain a high index of suspicion for atypical presentations of amyloidosis, especially in individuals with chronic inflammation, enabling early diagnosis and tailored management for improved patient outcomes.
Gastrointestinal amyloidosis is a rare condition often associated with chronic inflammation. We present a unique case of a 50-year-old female with a history of miliary tuberculosis who developed gastrointestinal amyloidosis. The patient exhibited chronic loose stools, weight loss, abdominal pain, and urinary incontinence symptoms. Diagnostic workup revealed characteristic findings of amyloidosis on biopsy. Despite treatment for tuberculosis, her symptoms persisted, highlighting the challenging nature of managing this condition. This case underscores the importance of considering tuberculosis as a potential cause of secondary amyloidosis in patients with ongoing symptoms of inflammation and infection. Early recognition and tailored management are crucial in optimizing patient outcomes.
该病例强调了即使在既往接受过感染治疗的患者中，也应将结核病视为胃肠道淀粉样变性的潜在病因。临床医生应对淀粉样变性的非典型表现保持高度怀疑，尤其是在患有慢性炎症的个体中，以便早期诊断并进行针对性管理，从而改善患者预后。
胃肠道淀粉样变性是一种罕见疾病，常与慢性炎症相关。我们报告了一例独特病例，一名50岁女性，有粟粒性结核病史，发生了胃肠道淀粉样变性。该患者表现出慢性腹泻、体重减轻、腹痛和尿失禁症状。诊断性检查在活检中发现了淀粉样变性的特征性表现。尽管接受了结核病治疗，但其症状仍持续存在，凸显了管理这种疾病的挑战性。该病例强调了在有持续炎症和感染症状的患者中，将结核病视为继发性淀粉样变性潜在病因的重要性。早期识别和针对性管理对于优化患者预后至关重要。
